CAS Number1119-62-6
SynonymsMFCD00002780; 3-(2-carboxyethyldisulfanyl)propanoic acid; 3,3'-Dithiodipropionic acid; 3,3'-Disulfanediyldipropanoic acid; EINECS 214-284-0; 3,3-Dithiodipropionic Acid; 3,3'-Dithiodipropionic acid
Molecular FormulaHOCOCH2CH2SSCH2CH2COOH
Molecular Weight210.27
Purity95%
Density1.5±0.1 g/cm3
Boiling Point431.1±30.0 °C at 760 mmHg
Melting Point155-158 °C (lit.)
Appearanceoff-white powder
EINECS214-284-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1119-62-6 |
| Catalog No. | 2A-9026180 |
| Chinese Name | 3,3'-二硫代二丙酸 |
| Synonyms | MFCD00002780; 3-(2-carboxyethyldisulfanyl)propanoic acid; 3,3'-Dithiodipropionic acid; 3,3'-Disulfanediyldipropanoic acid; EINECS 214-284-0; 3,3-Dithiodipropionic Acid; 3,3'-Dithiodipropionic acid |
| Molecular Formula | HOCOCH2CH2SSCH2CH2COOH |
| Molecular Weight | 210.27 |
| Purity | 95 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 431.1±30.0 °C at 760 mmHg |
| Melting Point | 155-158 °C (lit.) |
| Appearance | off-white powder |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Packaging | III |
| Application | Dithiodipropionic acid can interact with CPUL1 (HY-151802, TrxR inhibitor) to form nanoaggregates (CPUL1-DA NA). Compared with free CPUL1, CPUL1-DA NAs produce more abundant ROS to induce apoptosis an |
| EINECS | 214-284-0 |
| HTC | 2930909090 |
| PubChem ID | 24846851 |
| MDL Number | MFCD00002780 |
| SMILES | OC(=O)CCSSCCC(O)=O |
| InChI | 1S/C6H10O4S2/c7-5(8)1-3-11-12-4-2-6(9)10/h1-4H2,(H,7,8)(H,9,10) |
| InChI Key | YCLSOMLVSHPPFV-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1778543 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 8 |
| MSDS | msds/26180_1_1119_62_6.pdf |
| Bioactivity | Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer In Vitro CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC50 value of 4.3 μM, and has weak cytotoxicity against normal L02 cells[1]. CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1[1]. CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells[1]. References [1]. Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 431.1±30.0 °C at 760 mmHg Melting Point 155-158 °C(lit.) Molecular Formula C6H10O4S2 Molecular Weight 210.271 Flash Point 214.5±24.6 °C Exact Mass 210.002045 PSA 125.20000 LogP 1.38 Vapour Pressure 0.0±2.2 mmHg at 25°C Index of Refraction 1.592 InChIKey YCLSOMLVSHPPFV-UHFFFAOYSA-N SMILES O=C(O)CCSSCCC(=O)O |
| Use of | Properties Name 3,3′-Dithiodipropionic acid Synonym More Synonyms 3,3'-Disulfanediyldipropanoic acid Biological Activity Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir. Chemical & Physical Properties Molecular Formula C6H10O4S2 Exact Mass 210.002045 PSA 125.20000 Index of Refraction 1.592 InChIKey YCLSOMLVSHPPFV-UHFFFAOYSA-N SMILES O=C(O)CCSSCCC(=O)O |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Land Transport Dangerous Regulations: -International Maritime Transport Dangerous Regulations: -International Air Transport Dangerous Regulations: 3335 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods Aviation regulated solid, n.o.s. (3,3'-Dithiobispropionic acid) 14.3 Transport hazard categories European land transport danger code: -International sea transport danger code: -International air transport danger code: 9 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Transport Dangerous Regulations: -International Air Transport Dangerous Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
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