CAS Number1118-90-7
SynonymsL-2-Aminoadipic acid; 2-Aminohexanedioic acid; 2-aminoadipic acid; AAD; MFCD00002636; a-Aminoadipate; DL-2-Aminohexanedioic acid; (S)-2-Aminohexanedioic acid,L-Homoglutamic acid,Aad; α-Amino-adipic acid; UNII:1K7B1OED4N; L-a-Aminoadipic acid; DL-a-aminoadipic acid; (S)-2-Aminohexanedioic acid; a-Aminoadipic acid; (2S)-2-Aminohexanedioic acid; (±)-2-Aminoadipic acid
Molecular FormulaHO2C(CH2)3CH(NH2)CO2H
Molecular Weight161.16
Purity≥98 (TLC)%
Density1.3±0.1 g/cm3
Boiling Point364.0±32.0 °C at 760 mmHg
Melting Point203-205 °C (dec.) (lit.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1118-90-7 |
| Catalog No. | 2A-9026173 |
| Chinese Name | L-2-氨基己二酸 |
| Synonyms | L-2-Aminoadipic acid; 2-Aminohexanedioic acid; 2-aminoadipic acid; AAD; MFCD00002636; a-Aminoadipate; DL-2-Aminohexanedioic acid; (S)-2-Aminohexanedioic acid,L-Homoglutamic acid,Aad; α-Amino-adipic acid; UNII:1K7B1OED4N; L-a-Aminoadipic acid; DL-a-aminoadipic acid; (S)-2-Aminohexanedioic acid; a-Aminoadipic acid; (2S)-2-Aminohexanedioic acid; (±)-2-Aminoadipic acid |
| Molecular Formula | HO2C(CH2)3CH(NH2)CO2H |
| Molecular Weight | 161.16 |
| Purity | ≥98 (TLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 364.0±32.0 °C at 760 mmHg |
| Melting Point | 203-205 °C (dec.) (lit.) |
| Appearance | powder |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Application | (S)-2-Aminoadipic acid is a biochemical reagent that can be used as a biological material or organic compound in life science-related research. |
| HTC | 2922499990 |
| PubChem ID | 24278234 |
| MDL Number | MFCD00002636 |
| SMILES | N[C@@H](CCCC(O)=O)C(O)=O |
| InChI | 1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1 |
| InChI Key | OYIFNHCXNCRBQI-BYPYZUCNSA-N |
| Beilstein/REAXYS | 1724348 |
| NACRES Code | NA.32 |
| UNSPSC | 12352209 |
| Hazard Symbols | transportation |
| MSDS | msds/26173_1_1118_90_7.pdf |
| Bioactivity | (S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Related Catalog Research Areas >> Others In Vitro Ki value 209 μML-α-Aminoadipic Acid is a glutamine synthetase inhibitor. Glutamine synthetase is an enzyme that plays an important role in nitrogen metabolism by catalyzing the condensation of glutamate and ammonia to form glutamine. In vitro: Previous studies found that DL- and L-alpha-aminoadipic acid (alpha-AA) have specific gliotoxin in vitro. HPLC analysis of cultures incubated with D- or L-α-AA and DL-[14C]-α-AA autoradiograms in the presence of D- or L-α-AA demonstrates stereospecificity of astroglial L-α-AA uptake. Both alpha-AA uptake by astrocytes and alpha-AA-induced glial cytotoxicity are sodium-dependent. Another study found that the L-isomer of α-aminoadipic acid was able to competitively inhibit the transporter, whereas the D-isomer of α-aminoadipic acid was ineffective. Furthermore, L-α aminoadipic acid was found to be a competitive inhibitor of glutamine synthetase and γ-glutamylcysteine synthetase. In contrast, the D-isomer of α-aminoadipic acid inhibits both enzymes much less strongly. In vivo: Animal studies have shown that La-aminoadipic acid can dose-dependently reduce levels of endogenous extracellular kynurenic acid in the hippocampus (endent fashion), although La-aminoadipic acid appears to be less effective than it does in reducing de novo kynurenic acid. Clinical Trials: To date, no clinical studies have been conducted. References: Huck, S., Grass, F. and Hrtnagl, H. The glutamate analog α-aminoadipic acid is taken up by astrocytes before exerting its neurotoxic effects in vitro. Journal of Neuroscience 4(10), 2650-2657 (1984). McBean GJ. Inhibitory effects of gliotoxin alpha-aminoadipic acid on glutamate transporters and glial enzymes in the rat striatum. Br J Pharmacol. 1994 Oct;113(2):536-40. Wu HQ, Ungerstedt U, Schwarcz R. L-alpha-aminoadipic acid as a modulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats. European Journal of Pharmacology. 1995 Jul 25;281(1):55-61. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 364.0±32.0 °C at 760 mmHg Melting Point 203-205ºC (dec.) Molecular Formula C6H11NO4 Molecular Weight 161.16 Flash Point 173.9±25.1 °C Exact Mass 161.068802 PSA 100.62000 LogP -0.54 Vapor Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.515 InChIKey OYIFNHCXNCRBQI-BYPYZUCNSA-N SMILES NC(CCCC(=O)O)C(=O)O |
| Use of | (S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Properties Name L-2-aminoadipic acid Synonym More Synonyms α-Aminoadipic acid Biological Activity Description (S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Related Catalog Research Areas >> Others Chemical & Physical Properties Molecular Formula C6H11NO4 Exact Mass 161.068802 PSA 100.62000 LogP -0.54 Index of Refraction 1.515 InChIKey OYIFNHCXNCRBQI-BYPYZUCNSA-N SMILES NC(CCCC(=O)O)C(=O)O |
| Tax Rebate | 9.0% |
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| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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