CAS Number863-57-0
SynonymsGlycine, N-choloyl-, monosodium salt; EINECS 212-730-9; sodium {[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate; GLYCOCHOLIC ACID SODIUM SALT; MFCD00036741; Sodium {[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate; Glycine, N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1); Sodium glycocholate hydrate; glycine, N-[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1)
Molecular FormulaC26H42NNaO6
Molecular Weight487.604
Purity100.1 dry basis (titration)%
Boiling Point692ºC at 760 mmHg
Melting Point210-215 °C (subl.)(lit.)
Appearancesolid
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 863-57-0 |
| Catalog No. | 2A-9025430 |
| Chinese Name | 甘氨胆酸钠 |
| Synonyms | Glycine, N-choloyl-, monosodium salt; EINECS 212-730-9; sodium {[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate; GLYCOCHOLIC ACID SODIUM SALT; MFCD00036741; Sodium {[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate; Glycine, N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1); Sodium glycocholate hydrate; glycine, N-[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1) |
| Molecular Formula | C26H42NNaO6 |
| Molecular Weight | 487.604 |
| Purity | 100.1 dry basis (titration) |
| Boiling Point | 692ºC at 760 mmHg |
| Melting Point | 210-215 °C (subl.)(lit.) |
| Appearance | solid |
| Storage Condition | Store sealed and dry. |
| Application | Sodium glycolate is an orally active bile acid with anticancer activity targeting pump resistance-related and non-pump resistance-related pathways [1]. |
| MDL Number | MFCD00669624 |
| SMILES | [Na+].N(CC(=O)[O-])C(=O)CCC(C1C2(C(C3C(C4(C(CC3O)CC(CC4)O)C)CC2O)CC1)C)C |
| InChI | 1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1 |
| InChI Key | OABYVIYXWMZFFJ-UHFFFAOYSA-M |
| NACRES Code | NA.21 |
| UNSPSC | 12352106 |
| MSDS | msds/25430_1_863_57_0.pdf |
| Bioactivity | Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1]. Related Catalog Research Areas >> Others Target Microbial Metabolite Human Endogenous Metabolite In Vitro Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1]. Chemical & Physical Properties Boiling Point 692ºC at 760 mmHg Melting Point 210-215 °C (subl.)(lit.) Molecular Formula C26H42NNaO6 Molecular Weight 487.604 Flash Point 372.3ºC Exact Mass 487.290985 PSA 129.92000 LogP 1.62110 Index of Refraction 30 ° (C=1, H2O) InChIKey OABYVIYXWMZFFJ-UHFFFAOYSA-M SMILES CC(CCC(=O)NCC(=O)[O-])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.[Na+] Storage condition Refrigerator |
| Use of | Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1]. Properties Name sodium glycocholate Synonym More Synonyms sodium glycocholate Biological Activity Description Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1]. Related Catalog Research Areas >> Others Microbial Metabolite Human Endogenous Metabolite Chemical & Physical Properties Molecular Formula C26H42NNaO6 Exact Mass 487.290985 PSA 129.92000 LogP 1.62110 InChIKey OABYVIYXWMZFFJ-UHFFFAOYSA-M Storage condition Refrigerator |
| Transport Info | Product name: Sodium glycocholate |
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