CAS Number863-61-6
Synonyms[R-[R*,R*-(Z)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; cis-Phylloquinone; 2-methyl-3-((E)-3,7,11,15-tetramethyl-hexadec-2-enyl)-[1,4]naphthoquinone; Menatetrenone; 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl]naphthoquinone; Phytonadione,(Z); 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecaenyl]naphthoquinone; cis-Vitamin K1; MK 4; Phytomenadione,(Z); Phylloquinone,cis; 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]naphthalene-1,4-dione; 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthoquinone; K220; (E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-n
Molecular FormulaC31H40O2
Molecular Weight444.65
Purity98.00%
Density1.0±0.1 g/cm3
Boiling Point570.6±50.0 °C at 760 mmHg
Melting Point350ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 863-61-6 |
| Catalog No. | 2A-0202045 |
| Chinese Name | 维生素 K2 |
| Synonyms | [R-[R*,R*-(Z)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; cis-Phylloquinone; 2-methyl-3-((E)-3,7,11,15-tetramethyl-hexadec-2-enyl)-[1,4]naphthoquinone; Menatetrenone; 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl]naphthoquinone; Phytonadione,(Z); 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecaenyl]naphthoquinone; cis-Vitamin K1; MK 4; Phytomenadione,(Z); Phylloquinone,cis; 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]naphthalene-1,4-dione; 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthoquinone; K220; (E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-n |
| Molecular Formula | C31H40O2 |
| Molecular Weight | 444.65 |
| Purity | 98.00 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 570.6±50.0 °C at 760 mmHg |
| Melting Point | 350ºC |
| Appearance | powder |
| Storage Condition | Sealed storage at -20°C |
| Application | Menaquinone-4 is a form of vitamin K used as a hemostatic agent and as an adjunctive treatment in the treatment of osteoporosis. |
| PubChem ID | 329830240 |
| MDL Number | MFCD00079646 |
| SMILES | C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=C(C)C(=O)c2ccccc2C1=O |
| InChI | 1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+ |
| InChI Key | DKHGMERMDICWDU-GHDNBGIDSA-N |
| NACRES Code | NA.79 |
| UNSPSC | 12352205 |
| Hazard Symbols | transportation |
| MSDS | msds/25431_1_863_61_6.pdf |
| Bioactivity | Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Others In Vitro Menaquinone-4 (MK-4, 0, 1, 5, 10 μM) increases the ALP activity in Caco-2 cells. Menaquinone-4 (1 μM) significantly increases intensities of hSI expression[1]. In Vivo Menaquinone-4 (K2, 0.2 g/kg diet) in HF-K2 group produces epididymal fat in C57BL/6J mice, and also increases the bone density of mice[2]. Cell Assay Caco-2 cells are plated at a density of 2-5 × 104 cells/cm2 onto a 35-mm dish. Cells are incubated for 2 to 3 days until 60%-70% confluency, and desired concentrations of Menaquinone-4 (0, 1.0, 5.0, and 10.0 μM) are added. The final concentration of the vehicle is 0.1% of the culture medium, and the culture medium is changed twice a week. Cells are assayed on days 0, 3, 7, and 11 after the addition of Menaquinone-4[1]. Animal Admin Forty-two male, 4-week-old C57BL/6J mice provided with feed and drink ad libitum. For environmental adaptation, the animals had 1 week of circulation, and then are provided with the experimental diet after being randomly divided into 6 groups (7 animals in each group; randomized block design). The AIN-93G diets consist of a normal diet (N), normal diet + vitamin K1 (N-K1), normal diet + vitamin Menaquinone-4 (N-K2), 45% high-fat diet (HF), 45% high-fat diet + vitamin K1 (HF-K1), and a 45% high-fat diet + vitamin Menaquinone-4 (HF-K2). The vitamin K1 and vitamin Menaquinone-4 contents are 200 mg/1,000 g, and the diet is provided in pellet form. Body weight is measured once a week, and the food efficiency ratio (FER) is calculated by dividing the increased body weight from day 1 to the final day by the food intake amount during the experiment period. For fat amount measurement, the epididymal fat, perirenal fat, and retroperitoneal fat are extracted from dead animal subjects, are washed with 0.9% NaCl, dried by filter paper, and then are weighed[2]. References [1]. Noda S, et al. Menaquinone-4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells. Nutr Res. 2016 Nov;36(11):1269-1276. [2]. Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 570.6±50.0 °C at 760 mmHg Melting Point 350ºC Molecular Formula C31H40O2 Molecular Weight 444.648 Flash Point 208.3±27.1 °C Exact Mass 444.302826 PSA 34.14000 LogP 10.94 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.539 InChIKey DKHGMERMDICWDU-GHDNBGIDSA-N SMILES CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCC1=C(C)C(=O)c2ccccc2C1=O Storage condition −20°C |
| Use of | Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis. Properties Articles40 Name menatetrenone Synonym More Synonyms Menatetrenone Biological Activity Description Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Others References [2]. Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13. Chemical & Physical Properties Molecular Formula C31H40O2 Exact Mass 444.302826 PSA 34.14000 LogP 10.94 Index of Refraction 1.539 InChIKey DKHGMERMDICWDU-GHDNBGIDSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Methyl Red sodium salt | 845-10-3 | 2A-9025415 |
| 5a-Androstanedione | 846-46-8 | 2A-9025416 |
| Ethylmetrienone | 848-04-4 | 2A-9025419 |
| Tris(4-methoxyphenyl)phosphine | 855-38-9 | 2A-9025425 |
| Sodium glycocholate | 863-57-0 | 2A-9025430 |
| 1,1,2,2-Tetrahydroperfluoro dodecanol | 865-86-1 | 2A-9025437 |
| Copper citrate | 866-82-0 | 2A-9025438 |
| Triethyl phosphonoacetate | 867-13-0 | 2A-9025440 |
| Yttrium oxalate tetrahydrate | 867-68-5 | 2A-9025443 |
| Sodium D-pantothenate | 867-81-2 | 2A-9025444 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS