CAS Number532-43-4
SynonymsEINECS 208-537-4; MFCD00036330; Thiamin mononitrate; Thiaminenitrate; thiamin nitrate; thiamine,nitrate; Thiamine Nitrate; Vitanon; Thaimenitrate; thiaminium nitrate; Thiaminnitrat; VitaMin B1 HNO3; mnitrate
Molecular FormulaC12H17N5O4S
Molecular Weight327.36
Purity98.00%
Melting Point196-200°C
Appearancewhite crystal powder
EINECS208-537-4
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 532-43-4 |
| Catalog No. | 2A-9022584 |
| Chinese Name | 硝酸硫胺 |
| Synonyms | EINECS 208-537-4; MFCD00036330; Thiamin mononitrate; Thiaminenitrate; thiamin nitrate; thiamine,nitrate; Thiamine Nitrate; Vitanon; Thaimenitrate; thiaminium nitrate; Thiaminnitrat; VitaMin B1 HNO3; mnitrate |
| Molecular Formula | C12H17N5O4S |
| Molecular Weight | 327.36 |
| Purity | 98.00 |
| Melting Point | 196-200°C |
| Appearance | white crystal powder |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Application | Thiamine nitrate is an essential vitamin that enhances normal neuronal activity. |
| EINECS | 208-537-4 |
| HTC | 2934100090 |
| PubChem ID | 329823322 |
| MDL Number | MFCD00036330 |
| SMILES | [O-][N+]([O-])=O.CC1=NC=C(C[N+]2=CSC(CCO)=C2C)C(N)=N1 |
| InChI | 1S/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1 |
| InChI Key | UIERGBJEBXXIGO-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3857790 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/22584_1_532_43_4.pdf |
| Bioactivity | Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease In Vitro Thiamine levels in the blood of homozygous KO and KI mice fed a conventional diet are decreased to 0.058±0.051 and 0.126±0.092 μM, respectively, at 7 weeks compare to WT mice (0.796±0.259 μM). When WT and homozygous KO and KI mice are fed a Thiamine-restricted diet (Thiamine: 0.60 mg/100 g food), blood Thiamine concentration at 5 and 14 days is markedly decreased to 0.010±0.009 and 0.010±0.006 μM, respectively, compare to WT mice (0.609±0.288 μM). Thiamine concentration in brain homogenate of WT mice fed a conventional diet is 3.81±2.18 nmol/g wet weight, and that of KO and KI is 1.33±0.96 and 2.16±1.55 nmol/g wet weight, respectively. Notably, Thiamine concentration in brain homogenate decreases steadily in KO and KI mice fed a thiamine-restrict diet (Thiamine: 0.60 mg/100 g food) for 5 days (0.95±0.72 nmol/g wet weight) and 14 days (1.11±0.24 nmol/g wet weight), respectively, compare to WT (3.65±1.02 nmol/g wet weight), before the mice presenting an phenotype of disease[2]. In Vivo WT, homozygous, and heterozygous KO and KI mice fed a conventional diet (thiamine: 1.71 mg/100 g) survive for over 6 months without any phenotype of disease. Homozygous KO and KI mice fed a Thiamine-restricted diet (thiamine: 0.60 mg/100 g food) show paralysis, weight loss, and immobility, and die within 12 and 30 days, respectively. Similarly, homozygous KO and KI mice fed a Thiamine-restricted diet with an even lower percentage of Thiamine (Thiamine: 0.27 mg/100 g food) die within 14 and 18 days, respectively. However, WT and heterozygous KO and KI mice fed a Thiamine-restricted diet (Thiamine: 0.60 mg or 0.27 mg/100g food) survive for over 6 months without any phenotype of disease[2]. Animal Admin Slc19a3 E314Q KI mice are maintained routinely with conventional diet, which has a Thiamine concentration (thiamine hydrochloride, MW=337.3) of 1.71 mg/100 g food. Two types of Thiamine-restrict food base on "purified diets for laboratory rodents" are prepared, in which Thiamine concentration is 0.60 mg/100 g food (35% Thiamine of conventional food) or 0.27 mg/100 g food (16% Thiamine of conventional food). A high-Thiamine-containing food is also prepared from AIN-93M, in which Thiamine concentration is five times that of CE-2 (thiamine: 8.50 mg/100 g food)[2]. References [1]. Kenneth Osiezagha, et al.Thiamine Deficiency and Delirium. Innov Clin Neurosci. 2013 Apr; 10(4): 26-32. [2]. Kaoru Suzuki, et al. High-dose thiamine prevents brain lesions and prolongs survival ofSlc19a3-deficient mice. PLoS One. 2017; 12(6): e0180279. Chemical & Physical Properties Melting Point 196-200°C Molecular Formula C12H17N5O4S Molecular Weight 327.359 Exact Mass 327.100128 PSA 173.03000 LogP 1.47300 InChIKey UIERGBJEBXXIGO-UHFFFAOYSA-N SMILES Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1.O=[N+]([O-])[O-] Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives. Properties Name Thiamine nitrate Synonym More Synonyms Thiamine nitrate Biological Activity Description Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Kenneth Osiezagha, et al.Thiamine Deficiency and Delirium. Innov Clin Neurosci. 2013 Apr; 10(4): 26-32. [2]. Kaoru Suzuki, et al. High-dose thiamine prevents brain lesions and prolongs survival ofSlc19a3-deficient mice. PLoS One. 2017; 12(6): e0180279. Chemical & Physical Properties Molecular Formula C12H17N5O4S Exact Mass 327.100128 PSA 173.03000 LogP 1.47300 InChIKey UIERGBJEBXXIGO-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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