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(+)-Bicuculline

Name: (+)-Bicuculline
Brand: 2A Biotech
SKU: 2A-9022183

CAS Number485-49-4

SynonymsD-BICUCULLINE; EINECS 207-619-7; BICUCULLINE (+); (+)-Bicuculline; PLUS-BICUCULLINE; bicucculine; MFCD00005006; Bicuculline; bicucullin

Molecular FormulaC20H17NO6

Molecular Weight367.35

Purity≥98 (HPLC)%

Density1.5±0.1 g/cm3

Boiling Point542.3±50.0 °C at 760 mmHg

Melting Point196-198 ºC

Appearancesolid

MSDSChinese English

Symbol

Signal WordWarning

Cat. No.: 2A-9022183 Purity: ≥98 (HPLC)%

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Quality Control of [ 485-49-4 ] Purity: ≥98 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	485-49-4
Catalog No.	2A-9022183
Chinese Name	(+)-荷包牡丹碱；右旋荷包牡丹碱；毕枯枯林；山乌龟碱
Synonyms	D-BICUCULLINE; EINECS 207-619-7; BICUCULLINE (+); (+)-Bicuculline; PLUS-BICUCULLINE; bicucculine; MFCD00005006; Bicuculline; bicucullin
Molecular Formula	C20H17NO6
Molecular Weight	367.35
Purity	≥98 (HPLC)
Density	1.5±0.1 g/cm3
Boiling Point	542.3±50.0 °C at 760 mmHg
Melting Point	196-198 ºC
Appearance	solid
Water Solubility	Soluble in: benzene; slightly soluble in: chlorofo
Storage Condition	This product should be sealed and stored dry at 4°
Packaging	III
Application	(+)-Bicuculline is a light-sensitive GABA-A receptor competitive antagonist.
MDL Number	MFCD00005006
SMILES	N1([C@@H](c5c(cc6c(c5)OCO6)CC1)[C@@H]2OC(=O)c3c4c(ccc32)OCO4)C
InChI	1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChI Key	IYGYMKDQCDOMRE-ZWKOTPCHSA-N
NACRES Code	NA.77
UNSPSC	12352200
Hazard Symbols	6.1(b)
MSDS	msds/22183_1_485_49_4.pdf
Bioactivity	(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Alkaloid Research Areas >> Others References [1]. Zahm DS, et al. Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. Brain Struct Funct. 2014 Mar;219(2):511-26. [2]. Johnston GA. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May;169(2):328-36. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 542.3±50.0 °C at 760 mmHg Melting Point 196-198 ºC Molecular Formula C20H17NO6 Molecular Weight 367.352 Flash Point 281.8±30.1 °C Exact Mass 367.105591 PSA 66.46000 LogP 2.88 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.665 InChIKey IYGYMKDQCDOMRE-ZWKOTPCHSA-N SMILES CN1CCc2cc3c(cc2C1C1OC(=O)c2c1ccc1c2OCO1)OCO3
Use of	(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor. Properties Articles185 Name bicuculline Synonym More Synonyms (+)-Bicuculline Biological Activity Description (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Alkaloid Research Areas >> Others References [1]. Zahm DS, et al. Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. Brain Struct Funct. 2014 Mar;219(2):511-26. [2]. Johnston GA. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May;169(2):328-36. Chemical & Physical Properties Molecular Formula C20H17NO6 Exact Mass 367.105591 PSA 66.46000 Index of Refraction 1.665 InChIKey IYGYMKDQCDOMRE-ZWKOTPCHSA-N
Transport Info	Product name: Purity: 98.0%
MSDS Transport Info	Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 1544 Formal shipping name: Alkaloid, solid, not otherwise specified Packing grade: III

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(+)-Bicuculline

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