CAS Number476-70-0
SynonymsBoldine chloroform; Boldin; 2,6-dihydroxy-3,5-dimethoxyaporphine; 5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol; EINECS 207-509-9; 1,10-dimethoxy-2,9-dihydroxyaporphine; Uniboldina; MFCD00135040; 2,9-Dihydroxy-1,10-dimethoxyaporphine; 1,10-Dimethoxy-6aa-aporphine-2,9-diol; dl-Boldine; Boldine; 1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
Molecular FormulaC19H21NO4
Molecular Weight327.37
Purity≥98 (TLC)%
Density1.3±0.1 g/cm3
Boiling Point529.3±50.0 °C at 760 mmHg
Melting Point157-164 °C
EINECS207-509-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 476-70-0 |
| Catalog No. | 2A-9022113 |
| Chinese Name | 波尔定碱 |
| Synonyms | Boldine chloroform; Boldin; 2,6-dihydroxy-3,5-dimethoxyaporphine; 5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol; EINECS 207-509-9; 1,10-dimethoxy-2,9-dihydroxyaporphine; Uniboldina; MFCD00135040; 2,9-Dihydroxy-1,10-dimethoxyaporphine; 1,10-Dimethoxy-6aa-aporphine-2,9-diol; dl-Boldine; Boldine; 1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol |
| Molecular Formula | C19H21NO4 |
| Molecular Weight | 327.37 |
| Purity | ≥98 (TLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 529.3±50.0 °C at 760 mmHg |
| Melting Point | 157-164 °C |
| Storage Condition | This product should be sealed and stored away from |
| Packaging | III |
| Application | Boldine is an apomorphine isoquinoline alkaloid extracted from the roots of Litsea cubeba and has antioxidant, anti-inflammatory and cytoprotective effects. Boldine inhibits osteoclastogenesis, improv |
| EINECS | 207-509-9 |
| PubChem ID | 329773223 |
| MDL Number | MFCD00135040 |
| SMILES | COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c-2c34)cc1O |
| InChI | 1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1 |
| InChI Key | LZJRNLRASBVRRX-ZDUSSCGKSA-N |
| Beilstein/REAXYS | 94036 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/22113_1_476_70_0.pdf |
| Bioactivity | Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Target OPG/RANKL/RANK[1] References [1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 529.3±50.0 °C at 760 mmHg Melting Point 162-164ºC Molecular Formula C19H21NO4 Molecular Weight 327.374 Flash Point 273.9±30.1 °C Exact Mass 327.147064 PSA 62.16000 LogP 2.32 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.639 InChIKey LZJRNLRASBVRRX-ZDUSSCGKSA-N SMILES COc1cc2c(cc1O)CC1c3c(cc(O)c(OC)c3-2)CCN1C |
| Use of | Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1]. Properties Articles28 Name (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol Synonym More Synonyms Boldine Biological Activity Description Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology OPG/RANKL/RANK[1] References [1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123. Chemical & Physical Properties Molecular Formula C19H21NO4 Exact Mass 327.147064 PSA 62.16000 Index of Refraction 1.639 InChIKey LZJRNLRASBVRRX-ZDUSSCGKSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Alkaloids | ||
|---|---|---|
| (-)-Pseudoephedrine | 321-97-1 | 2A-9021272 |
| Brucine | 357-57-3 | 2A-9021483 |
| Capsaicin | 404-86-4 | 2A-9021759 |
| Harmine | 442-51-3 | 2A-9021859 |
| Isocorydine | 475-67-2 | 2A-9022107 |
| Cytisine | 485-35-8 | 2A-9022181 |
| Cinchonidine | 485-71-2 | 2A-9022185 |
| (1R,2S)-Norephedrine | 492-41-1 | 2A-9022237 |
| L-(-)-Anabasine | 494-52-0 | 2A-9022248 |
| Hydroquinine | 522-66-7 | 2A-9022487 |
| Browse all Alkaloids products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS