CAS Number475-67-2
Synonymsartabotrin; 1,2,10-Trimethoxy-6aa-aporphin-11-ol; d-isocorydine; (6aS)-1,2,10-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol; luteanin; isocorydine; (S)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol; iso-Corydine; LUTEANINE
Molecular FormulaC20H23O4N1
Molecular Weight341.41
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point506.1±50.0 °C at 760 mmHg
Melting Point216-220ºC(lit.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 475-67-2 |
| Catalog No. | 2A-9022107 |
| Chinese Name | 异紫堇定 |
| Synonyms | artabotrin; 1,2,10-Trimethoxy-6aa-aporphin-11-ol; d-isocorydine; (6aS)-1,2,10-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol; luteanin; isocorydine; (S)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol; iso-Corydine; LUTEANINE |
| Molecular Formula | C20H23O4N1 |
| Molecular Weight | 341.41 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 506.1±50.0 °C at 760 mmHg |
| Melting Point | 216-220ºC(lit.) |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Isocorydine was isolated from the medlock nematode Dicranostigma leptopodum (Maxim.) Fedde. Isocorydine combined with doxorubicin (DOX) has the potential to eliminate hepatocellular carcinoma (HCC). |
| MDL Number | MFCD00075905 |
| SMILES | COc1ccc2c(c1O)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3 |
| InChI | InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1 |
| InChI Key | QELDJEKNFOQJOY-ZDUSSCGKSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/22107_1_475_67_2.pdf |
| Bioactivity | Isocorydine is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others In Vitro Isocorydine (0-400 ug/ml; 48 hours) show a significant decrease in the IC50 for ICD and DOX, the CI values are 0.605, 0.644, 0.804, and 0.707 respectively for Huh-7, Hep-G2, SNU-449 and SNU-387[1]. Isocorydine (0-400 ug/ml; 48 hours) abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines[1]. Cell Viability Assay[1] Cell Line: Huh-7, Hep-G2 , SNU-387, SNU-449 cells Concentration: 0-400 ug/ml Incubation Time: 24 hours Result: Had a higher cytotoxicity in HCC cells in comparison to ICD or DOX alone. Western Blot Analysis[1] Cell Line: Huh-7, Hep-G2 , SNU-387, SNU-449 cells Concentration: Incubation Time: 24 hours Result: Downregulated protein levels of Claundin-1 and E-cadherin. In Vivo Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth[1]. Animal Model: Female nude mice[1] Dosage: 0.4 mg/ml Administration: Injected intraperitoneally every 2 days for 2 weeks Result: Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC. References [1]. Pan JX, et al. Isocorydine suppresses doxorubicin-induced epithelial-mesenchymal transition via inhibition of ERK signaling pathways in hepatocellular carcinoma. Am J Cancer Res. 2018 Jan 1;8(1):154-164. eCollection 2018. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 506.1±50.0 °C at 760 mmHg Melting Point 216-220ºC(lit.) Molecular Formula C20H23NO4 Molecular Weight 341.401 Flash Point 259.9±30.1 °C Exact Mass 341.162720 PSA 51.16000 LogP 3.09 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.604 InChIKey QELDJEKNFOQJOY-ZDUSSCGKSA-N SMILES COc1ccc2c(c1O)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3 Storage condition -20℃ |
| Use of | Isocorydine is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC)[1]. Properties Name isocorydine hydrochloride Synonym More Synonyms (+)-Isocorynoline Biological Activity Description Isocorydine is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Pan JX, et al. Isocorydine suppresses doxorubicin-induced epithelial-mesenchymal transition via inhibition of ERK signaling pathways in hepatocellular carcinoma. Am J Cancer Res. 2018 Jan 1;8(1):154-164. eCollection 2018. Chemical & Physical Properties Molecular Formula C20H23NO4 Exact Mass 341.162720 PSA 51.16000 Index of Refraction 1.604 InChIKey QELDJEKNFOQJOY-ZDUSSCGKSA-N Storage condition -20℃ |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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