CAS Number464-43-7
Synonymsoct-7-ene-2,5-dione; oct-7-en-2,5-dion; EINECS 207-352-6; (2S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol; (+)-BORNEOL; MFCD00066427
Molecular FormulaC10H18O
Molecular Weight154.25
Purity97%
Density1.0±0.1 g/cm3
Boiling Point212.0±0.0 °C at 760 mmHg
Melting Point206-209 °C (lit.)
Appearancesolid
EINECS207-352-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 464-43-7 |
| Catalog No. | 2A-9022062 |
| Chinese Name | 右莰醇 |
| Synonyms | oct-7-ene-2,5-dione; oct-7-en-2,5-dion; EINECS 207-352-6; (2S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol; (+)-BORNEOL; MFCD00066427 |
| Molecular Formula | C10H18O |
| Molecular Weight | 154.25 |
| Purity | 97 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 212.0±0.0 °C at 760 mmHg |
| Melting Point | 206-209 °C (lit.) |
| Appearance | solid |
| Storage Condition | This product should be kept away from fire, sealed |
| Packaging | III |
| Application | (+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used in traditional Chinese medicine for analgesia and anesthesia. The EC50 value for enhancing GABA receptor activity is 248 μM. |
| EINECS | 207-352-6 |
| HTC | 2906199090 |
| PubChem ID | 24866321 |
| MDL Number | MFCD00066427 |
| SMILES | [H][C@@]12CC[C@@](C)([C@@H](O)C1)C2(C)C |
| InChI | 1S/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3/t7-,8+,10+/m1/s1 |
| InChI Key | DTGKSKDOIYIVQL-WEDXCCLWSA-N |
| Beilstein/REAXYS | 2038056 |
| NACRES Code | NA.22 |
| UNSPSC | 12352212 |
| Hazard Symbols | 4.1 |
| MSDS | msds/22062_1_464_43_7.pdf |
| Bioactivity | (+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Inflammation/Immunology Natural Products >> Terpenoids and Glycosides Target EC50: 248 μM (GABA receptor)[1] In Vitro (+)-Borneol is present in the essential oils of numerous medicinal plants, including valerian (Valeriana officinalis), chamomile (Matricaria chamomilla) and lavender (Lavandula officinalis). Extracts of these plants are used traditionally to relieve anxiety, restlessness and insomnia. (+)-Borneol is found to have a highly efficacious positive modulating action at GABAA receptors. (+)-Borneol enhances the action of low concentrations of GABA by more than 1000% (EC50=248 μM)[1]. In Vivo (+)-Borneol has remarkable anti-hyperalgesic effects on neuropathic and inflammatory pain in animal models. Both oral administration (125, 250 or 500 mg/kg) and intrathecal injection (i.t.) (15, 30 and 60 μg) of (+)-Borneol reduce mechanical hypersensitivity dose-dependently in SNL and CFA models. The antihyperalgesic effects of (+)-Borneol are abolished by a selective GABAA receptor (GABAAR) antagonist bicuculline. (+)-Borneol (500 mg/kg, p.o. or 60 μg, i.t.) does not influence motor function[2]. After per oral application, (+)-Borneol is absorbed rapidly into the brain and could be determined 5 min after dosing. The maximal brain concentration (86.52 μg/g) is reached after 1 h post-dosing. (+)-Borneol could affect the contents of AA neurotransmitters in mice brain and the change in excitatory ratio leads to borneol's double side effects on the central nervous system[3]. Animal Admin Mice: Inflammatory pain is induced by injection of Complete Freund's adjuvant (CFA, 1 mg/mL). Ten min later mice are treated with (+)-Borneol (125, 250, 500 mg/kg) or vehicle. Mechanical hypersensitivity is then measured[2]. References [1]. Granger RE, et al. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol. 2005 Apr 1;69(7):1101-11. [2]. Jiang J, et al. (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. Eur J Pharmacol. 2015 Jun 15;757:53-8. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 212.0±0.0 °C at 760 mmHg Melting Point 206-209ºC(lit.) Molecular Formula C10H18O Molecular Weight 154.249 Flash Point 80.7±10.9 °C Exact Mass 154.135757 PSA 20.23000 LogP 2.71 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.502 |
| Use of | (+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. Properties Articles29 Name (+)-borneol Synonym More Synonyms (+)-Borneol Biological Activity Description (+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Inflammation/Immunology Natural Products >> Terpenoids and Glycosides EC50: 248 μM (GABA receptor)[1] In Vitro (+)-Borneol is present in the essential oils of numerous medicinal plants, including valerian (Valeriana officinalis), chamomile (Matricaria chamomilla) and lavender (Lavandula officinalis). Extracts of these plants are used traditionally to relieve anxiety, restlessness and insomnia. (+)-Borneol is found to have a highly efficacious positive modulating action at GABAA receptors. (+)-Borneol enhances the action of low concentrations of GABA by more than 1000% (EC50=248 μM)[1]. References [2]. Jiang J, et al. (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. Eur J Pharmacol. 2015 Jun 15;757:53-8. Chemical & Physical Properties Molecular Formula C10H18O Exact Mass 154.135757 PSA 20.23000 Index of Refraction 1.502 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 1312 International Dangerous Regulations for sea transport: 1312 International Dangerous Regulations for air transport: 1312 14.2 United Nations shipping name European Land Transport Danger Regulations: BORNEOL IMDG: BORNEOL International Air Transport Danger Regulations: Borneol 14.3 Transport hazard categories European Land Transport Danger Regulations: 4.1 International Maritime Transport Danger Regulations: 4.1 International Air Transport Danger Regulations: 4.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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