CAS Number322-35-0
Synonymsbensarazide; Benseraszide; Ro 4-4602; Benserazida; DL-Seryltrihydroxybenzylhydrazine; MFCD00242633; 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide; Serazide; Benserazidum
Molecular FormulaC10H15N3O5
Molecular Weight293.70
Purity98.00%
Density1.541 g/cm3
Boiling Point574.2ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 322-35-0 |
| Catalog No. | 2A-9021273 |
| Chinese Name | 苄丝肼 |
| Synonyms | bensarazide; Benseraszide; Ro 4-4602; Benserazida; DL-Seryltrihydroxybenzylhydrazine; MFCD00242633; 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide; Serazide; Benserazidum |
| Molecular Formula | C10H15N3O5 |
| Molecular Weight | 293.70 |
| Purity | 98.00 |
| Density | 1.541 g/cm3 |
| Boiling Point | 574.2ºC at 760 mmHg |
| Application | Benserazide is a PKM2 inhibitor. Benserazide directly binds and blocks PKM2 enzyme activity, thereby inhibiting aerobic glycolysis while upregulating OXPHOS. Benserazide is used in melanoma research. |
| HTC | 2928000090 |
| PubChem ID | 329773114 |
| MDL Number | MFCD00078571 |
| SMILES | Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O |
| InChI | 1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H |
| InChI Key | ULFCBIUXQQYDEI-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/21273_1_322_35_0.pdf |
| Use of | Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma[1]. Properties Name benserazide Synonym More Synonyms Biological Activity Description Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma[1]. Related Catalog Research Areas >> Cancer References [1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151. Chemical & Physical Properties Molecular Formula C10H15N3O5 Exact Mass 257.10100 PSA 148.07000 Index of Refraction 1.678 InChIKey BNQDCRGUHNALGH-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C10-H15-N3-O5 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - ataxia Kidney, Ureter, Bladder - other changes in urine composition Musculoskeletal - other changes REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 90 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 Safety Information Hazard Codes Xi Safety Phrases S26 HS Code 2928000090 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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