CAS Number156-57-0
Synonyms2-AMino&CYSTEAMINE HCL; 1-Amino-2-mercaptoethane hydrochloride; 2-aminoethylmercaptan hydrochloride; 2-Mercapto ethyl amine hydrochloride; EINECS 205-858-1; β-Mercapto ethylamine hydrochloride; CYSTEAMINE HCL SOLID; Cysteinamine Hydrochloride; thiol hydrochloride; 2-Mercaptoethylamine hydrochloride; Cysteamine Hydrochloride; 2-Aminoethanethiol hydrochloride (1:1); Cysteamine (Hydrochloride); 2-Aminoethanethiol Hydrochloride; Thioethanolamine hydrochloride; 2-Mercaptoethanamine Hydrochloride; CYSTEAMINIUM CHLORIDE; 2-Mercaptoethylamin; 2-amino-ethanethiol hydrochloride; 1-Aminoethane-2-thiol hydrochloride; Cysteamine HCl; mea hydrochloride; b-Mercaptoethylamine Hydrochloride; 2-Amino-ethanethiol.HCl; Ethanethiol, 2-amino-, hydrochloride (1:1); β-Mercaptoethylamine hydrochloride; MFCD0001290
Molecular FormulaHSCH2CH2NH2 · HCl
Molecular Weight113.61
Purity≥98 (titration)%
Density0.75
Boiling Point116.4ºC at 760 mmHg
Melting Point67-71 °C
Appearancepowder or crystals
EINECS205-858-1
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 156-57-0 |
| Catalog No. | 2A-9021054 |
| Chinese Name | 半胱胺盐酸盐 |
| Synonyms | 2-AMino&CYSTEAMINE HCL; 1-Amino-2-mercaptoethane hydrochloride; 2-aminoethylmercaptan hydrochloride; 2-Mercapto ethyl amine hydrochloride; EINECS 205-858-1; β-Mercapto ethylamine hydrochloride; CYSTEAMINE HCL SOLID; Cysteinamine Hydrochloride; thiol hydrochloride; 2-Mercaptoethylamine hydrochloride; Cysteamine Hydrochloride; 2-Aminoethanethiol hydrochloride (1:1); Cysteamine (Hydrochloride); 2-Aminoethanethiol Hydrochloride; Thioethanolamine hydrochloride; 2-Mercaptoethanamine Hydrochloride; CYSTEAMINIUM CHLORIDE; 2-Mercaptoethylamin; 2-amino-ethanethiol hydrochloride; 1-Aminoethane-2-thiol hydrochloride; Cysteamine HCl; mea hydrochloride; b-Mercaptoethylamine Hydrochloride; 2-Amino-ethanethiol.HCl; Ethanethiol, 2-amino-, hydrochloride (1:1); β-Mercaptoethylamine hydrochloride; MFCD0001290 |
| Molecular Formula | HSCH2CH2NH2 · HCl |
| Molecular Weight | 113.61 |
| Purity | ≥98 (titration) |
| Density | 0.75 |
| Boiling Point | 116.4ºC at 760 mmHg |
| Melting Point | 67-71 °C |
| Appearance | powder or crystals |
| Water Solubility | VERY SOLUBLE |
| Storage Condition | Store in a dry, cool and ventilated place to preve |
| Application | Cysteamine hydrochloride is used in nephrotic cystinosis and as an antioxidant. |
| EINECS | 205-858-1 |
| HTC | 2921199090 |
| PubChem ID | 24278088 |
| MDL Number | MFCD00012904 |
| SMILES | Cl[H].NCCS |
| InChI | 1S/C2H7NS.ClH/c3-1-2-4;/h4H,1-3H2;1H |
| InChI Key | OGMADIBCHLQMIP-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3590083 |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| Hazard Symbols | Transport |
| MSDS | msds/21054_1_156_57_0.pdf |
| Bioactivity | Cysteamine Hydrochloride is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease References [1]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92. [2]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6. Chemical & Physical Properties Density 0.75 Boiling Point 116.4ºC at 760 mmHg Melting Point 67-71 °C Molecular Formula C2H8ClNS Molecular Weight 113.610 Flash Point 24.2ºC Exact Mass 113.006599 PSA 64.82000 LogP 1.37720 Vapour Pressure 16.7mmHg at 25°C InChIKey OGMADIBCHLQMIP-UHFFFAOYSA-N SMILES Cl.NCCS Storage condition 2-8°C Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents. Water Solubility VERY SOLUBLE |
| Use of | Properties Articles67 Name Cysteamine hydrochloride Synonym More Synonyms Cysteamine Hydrochloride Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease References [1]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92. [2]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6. Chemical & Physical Properties Exact Mass 113.006599 PSA 64.82000 LogP 1.37720 InChIKey OGMADIBCHLQMIP-UHFFFAOYSA-N SMILES Cl.NCCS Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents. Water Solubility VERY SOLUBLE |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Land Transport Dangerous Regulations: -International Maritime Transport Dangerous Regulations: -International Air Transport Dangerous Regulations: 3335 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods Aviation regulated solid, n.o.s. (Mercaptamine hydrochloride) 14.3 Transport hazard categories European land transport danger code: -International sea transport danger code: -International air transport danger code: 9 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Transport Dangerous Regulations: -International Air Transport Dangerous Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available If applicable, the chemical meets the requirements of the Regulations on the Safety Management of Hazardous Chemicals (adopted by the State Council on January 9, 2002). |
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