CAS Number138-56-7
SynonymsTebamide; Trimethobenzamid; EINECS 205-332-1; Trimethobenzamidum; Trimazide; Benzacot; trimethobenzamide; Tribenzagan; Tigan; Stemetic; Trimetobenzamida
Molecular FormulaC21H28O5N2
Molecular Weight388.46
Purity98.00%
Density1.131 g/cm3
Boiling Point506.9ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 138-56-7 |
| Catalog No. | 2A-9020812 |
| Chinese Name | N-(4-(2-(二甲基氨基)乙氧基)苄基)-3,4,5-三甲氧基苯甲酰胺 |
| Synonyms | Tebamide; Trimethobenzamid; EINECS 205-332-1; Trimethobenzamidum; Trimazide; Benzacot; trimethobenzamide; Tribenzagan; Tigan; Stemetic; Trimetobenzamida |
| Molecular Formula | C21H28O5N2 |
| Molecular Weight | 388.46 |
| Purity | 98.00 |
| Density | 1.131 g/cm3 |
| Boiling Point | 506.9ºC at 760 mmHg |
| Storage Condition | 2-8℃, dry, sealed |
| Application | Trimethylbenzamide (Ro 2-9578 free base) is a D2 receptor blocker. Trimethylbenzamide is an antiemetic drug used to prevent nausea and vomiting [1]. |
| HTC | 2924299090 |
| MDL Number | MFCD00599601 |
| SMILES | COc1cc(C(=O)NCc2ccc(OCCN(C)C)cc2)cc(OC)c1OC |
| InChI | InChI=1S/C21H28N2O5/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24) |
| InChI Key | FEZBIKUBAYAZIU-UHFFFAOYSA-N |
| MSDS | msds/20812_1_138_56_7.pdf |
| Use of | Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1]. Properties Name N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide Synonym More Synonyms Trimethobenzamide Biological Activity Description Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease D2 receptor[1] In Vitro Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1]. References [1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42. Chemical & Physical Properties Molecular Formula C21H28N2O5 Exact Mass 388.20000 PSA 69.26000 LogP 2.97370 InChIKey FEZBIKUBAYAZIU-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2924299090 Synthetic Route 4-[2-(dimethyla... CAS#:20059-73-8 Trimethylgalloy... CAS#:4521-61-3 Trimethobenzamide CAS#:138-56-7 Literature: US2879293 , ; 4-(2-(Dimethyla... CAS#:15182-92-0 Trimethobenzamide CAS#:138-56-7 Literature: US2879293 , ; 4-hydroxybenzal... CAS#:123-08-0 Trimethobenzamide CAS#:138-56-7 Literature: US2879293 , ; |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Cetrimonium tosylate | 138-32-9 | 2A-9020806 |
| Mafenide hydrochloride | 138-37-4 | 2A-9020807 |
| 4-Ethylbenzenesulfonamide | 138-38-5 | 2A-9020808 |
| Carzenide | 138-41-0 | 2A-9020809 |
| 4-Nitrobenzenesulfonic acid | 138-42-1 | 2A-9020810 |
| Chelidamic acid | 138-60-3 | 2A-9020814 |
| 3,4-Dihydroxyphenylglycine | 138-62-5 | 2A-9020815 |
| 4-Aminobenzoic acid potassium salt | 138-84-1 | 2A-9020816 |
| Sodium benzenolate | 139-02-6 | 2A-9020818 |
| Calcium bis(cyclohexylsulphamate) | 139-06-0 | 2A-9020820 |
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