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2,5-Dihydroxybenzoic acid structure, CAS 490-79-9

2,5-Dihydroxybenzoic acid

CAS Number490-79-9

SynonymsBenzoic acid,2,5-dihydroxy; Gentistic acid; Gensigon; 2,5-dihydroxyphenylcarboxylic acid; 2,5-DHBA,DHB,Gentisic acid; Gensigen; 2,5-Dihydroxybenzoic acid; Gentisate; 2,5-Dhba; Hydroquinonecarboxylic acid; 2,5-dihydroxybenzoate; 5-Hydroxysalicylic acid; EINECS 207-718-5; 2,5-Dioxybenzoic acid; 5-hydroxy-Salicylic acid; MFCD00002460; 2,5-Dihydroxy-benzoic acid; gentisic acid; 3,6-Dihydroxybenzoic Acid; 2,5-dihydroxy benzoic acid; Carboxyhydroquinone; DHB

Molecular Formula(HO)2C6H3CO2H

Molecular Weight154.12

Purity98%

Density1.6±0.1 g/cm3

Boiling Point406.9±35.0 °C at 760 mmHg

Melting Point204-208 °C (lit.)

Flash Point

Appearancepowder

EINECS207-718-5

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9002009 Purity: 98%
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Quality Control of [ 490-79-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number490-79-9
Catalog No.2A-9002009
Chinese Name2,5-二羟基苯甲酸
SynonymsBenzoic acid,2,5-dihydroxy; Gentistic acid; Gensigon; 2,5-dihydroxyphenylcarboxylic acid; 2,5-DHBA,DHB,Gentisic acid; Gensigen; 2,5-Dihydroxybenzoic acid; Gentisate; 2,5-Dhba; Hydroquinonecarboxylic acid; 2,5-dihydroxybenzoate; 5-Hydroxysalicylic acid; EINECS 207-718-5; 2,5-Dioxybenzoic acid; 5-hydroxy-Salicylic acid; MFCD00002460; 2,5-Dihydroxy-benzoic acid; gentisic acid; 3,6-Dihydroxybenzoic Acid; 2,5-dihydroxy benzoic acid; Carboxyhydroquinone; DHB
Molecular Formula(HO)2C6H3CO2H
Molecular Weight154.12
Purity98
Density1.6±0.1 g/cm3
Boiling Point406.9±35.0 °C at 760 mmHg
Melting Point204-208 °C (lit.)
Appearancepowder
Water Solubilitysoluble
Storage ConditionUse and store according to specifications, no deco
Application2,5-Dihydroxybenzoic acid is a metabolite of benzoic acid and a powerful inhibitor of fibroblast growth factor.
EINECS207-718-5
HTC29182990
PubChem ID24848948
MDL NumberMFCD00002460
SMILESOC(=O)c1cc(O)ccc1O
InChI1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)
InChI KeyWXTMDXOMEHJXQO-UHFFFAOYSA-N
Beilstein/REAXYS2209119
NACRES CodeNA.22
UNSPSC12352100
MSDSmsds/2009_1_490_79_9.pdf
Bioactivity2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Natural Products >> Acids and Aldehydes Research Areas >> Others Target Human Endogenous Metabolite Fibroblast growth factor In Vitro 2,5-Dihydroxybenzoic acid (Gentisic acid) is a derivative of benzoic and a minor product of the metabolic break down of aspirin[1]. 2,5-Dihydroxybenzoic acid is also a component of many traditional liquors and herbal remedies, is singled out as a powerful inhibitor of fibroblast growth factors. 2,5-Dihydroxybenzoic acid is used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it is shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis[2]. In Vivo It is verified from in vivo disease models that this group of inhibitors (e.g., 2,5-Dihydroxybenzoic acid) may be of interest to treat cancer and angiogenesis-dependent diseases[2]. References [1]. Levy G, et al. Salicylate accumulation kinetics in man. N Engl J Med. 1972 Aug 31;287(9):430-2. [2]. IS Fernández, et al. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. Journal of Biological Chemistry , 2010, 285(15):11714-29. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 406.9±35.0 °C at 760 mmHg Melting Point 204-208 °C(lit.) Molecular Formula C7H6O4 Molecular Weight 154.120 Flash Point 214.0±22.4 °C Exact Mass 154.026611 PSA 77.76000 LogP 1.56 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.671 InChIKey WXTMDXOMEHJXQO-UHFFFAOYSA-N SMILES O=C(O)c1cc(O)ccc1O Water Solubility soluble
Use of2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors. Properties Articles259 Name 2,5-dihydroxybenzoic acid Synonym More Synonyms Gentisic acid Biological Activity Description 2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Natural Products >> Acids and Aldehydes Research Areas >> Others Human Endogenous Metabolite Fibroblast growth factor In Vitro 2,5-Dihydroxybenzoic acid (Gentisic acid) is a derivative of benzoic and a minor product of the metabolic break down of aspirin[1]. 2,5-Dihydroxybenzoic acid is also a component of many traditional liquors and herbal remedies, is singled out as a powerful inhibitor of fibroblast growth factors. 2,5-Dihydroxybenzoic acid is used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it is shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis[2]. In Vivo It is verified from in vivo disease models that this group of inhibitors (e.g., 2,5-Dihydroxybenzoic acid) may be of interest to treat cancer and angiogenesis-dependent diseases[2]. References [1]. Levy G, et al. Salicylate accumulation kinetics in man. N Engl J Med. 1972 Aug 31;287(9):430-2. [2]. IS Fernández, et al. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. Journal of Biological Chemistry , 2010, 285(15):11714-29. Chemical & Physical Properties Molecular Formula C7H6O4 Exact Mass 154.026611 PSA 77.76000 Index of Refraction 1.671 InChIKey WXTMDXOMEHJXQO-UHFFFAOYSA-N Water Solubility soluble
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