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2,5-Dihydroxyacetophenone structure, CAS 490-78-8

2,5-Dihydroxyacetophenone

CAS Number490-78-8

Synonyms2,5-Dihydroxyphenyl methyl ketone,2-Acetyl-1,4-dihydroxybenzene,2-Acetylhydroquinone; 1-(2,5-Dihydroxyphenyl)ethanone; EINECS 207-716-4; 2-Acetylhydroquinone; MFCD00002343

Molecular Formula(HO)2C6H3COCH3

Molecular Weight152.15

Purity97%

Density1.3±0.1 g/cm3

Boiling Point329.2±27.0 °C at 760 mmHg

Melting Point204-206 °C (lit.)

Flash Point

Appearancecrystals

EINECS207-716-4

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9002008 Purity: 97%
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Quality Control of [ 490-78-8 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number490-78-8
Catalog No.2A-9002008
Chinese Name2',5'-二羟基苯乙酮
Synonyms2,5-Dihydroxyphenyl methyl ketone,2-Acetyl-1,4-dihydroxybenzene,2-Acetylhydroquinone; 1-(2,5-Dihydroxyphenyl)ethanone; EINECS 207-716-4; 2-Acetylhydroquinone; MFCD00002343
Molecular Formula(HO)2C6H3COCH3
Molecular Weight152.15
Purity97
Density1.3±0.1 g/cm3
Boiling Point329.2±27.0 °C at 760 mmHg
Melting Point204-206 °C (lit.)
Appearancecrystals
Water Solubilityinsoluble
Storage ConditionUse and store according to specifications, no deco
Application2,5-Dihydroxyacetophenone is isolated from Rehmannia glutinosa and can inhibit the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways.
EINECS207-716-4
HTC29145000
PubChem ID24893344
MDL NumberMFCD00002343
SMILESCC(=O)c1cc(O)ccc1O
InChI1S/C8H8O3/c1-5(9)7-4-6(10)2-3-8(7)11/h2-4,10-11H,1H3
InChI KeyWLDWSGZHNBANIO-UHFFFAOYSA-N
Beilstein/REAXYS637903
NACRES CodeNA.22
UNSPSC12352100
Hazard SymbolsTransport
MSDSmsds/2008_1_490_78_8.pdf
Bioactivity2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK Target ERK1 ERK2 NF-κB In Vitro 2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells[1]. References [1]. Han Y, et al. 2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatoryresponses in lipopolysaccharide-stimulated RAW264.7 macrophages. J Med Food. 2012 Jun;15(6):505-10. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 329.2±27.0 °C at 760 mmHg Melting Point 204-206 °C(lit.) Molecular Formula C8H8O3 Molecular Weight 152.147 Flash Point 167.1±20.2 °C Exact Mass 152.047348 PSA 57.53000 LogP 1.59 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.595 InChIKey WLDWSGZHNBANIO-UHFFFAOYSA-N SMILES CC(=O)c1cc(O)ccc1O Water Solubility insoluble
Use ofProperties Name 2',5'-Dihydroxyacetophenone Synonym More Synonyms 2,5-Dihydroxyacetophenone Biological Activity Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK References Chemical & Physical Properties Molecular Formula C8H8O3 Exact Mass 152.047348 PSA 57.53000 Index of Refraction 1.595 InChIKey WLDWSGZHNBANIO-UHFFFAOYSA-N Water Solubility insoluble
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Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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