CAS Number774549-97-2
Synonyms7-Chloro-4-{4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl}quinoline; 7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline; 7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazino}quinoline; KM 11060; KM11060
Molecular FormulaC19H17Cl2N3O2S
Molecular Weight422.328
Density1.5±0.1 g/cm3
Boiling Point607.3±65.0 °C at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 774549-97-2 |
| Catalog No. | 2A-1198815 |
| Chinese Name | KM11060 |
| Synonyms | 7-Chloro-4-{4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl}quinoline; 7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline; 7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazino}quinoline; KM 11060; KM11060 |
| Molecular Formula | C19H17Cl2N3O2S |
| Molecular Weight | 422.328 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 607.3±65.0 °C at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | KM11060 is F508del-CFTR calibrator. |
| HTC | 2935009090 |
| SMILES | O=S(=O)(c1ccc(Cl)cc1)N1CCN(c2ccnc3cc(Cl)ccc23)CC1 |
| InChI Key | GIEHIZKCIZLXLF-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2] Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Endocrinology References [1]. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89. [2]. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 607.3±65.0 °C at 760 mmHg Molecular Formula C19H17Cl2N3O2S Molecular Weight 422.328 Flash Point 321.1±34.3 °C Exact Mass 421.041840 PSA 61.89000 LogP 4.19 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.676 InChIKey GIEHIZKCIZLXLF-UHFFFAOYSA-N SMILES O=S(=O)(c1ccc(Cl)cc1)N1CCN(c2ccnc3cc(Cl)ccc23)CC1 Storage condition 2-8℃ |
| Use of | Properties Name 7-chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline Synonym More Synonyms KM 11060 Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Endocrinology References [1]. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89. [2]. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003. Chemical & Physical Properties Exact Mass 421.041840 PSA 61.89000 Index of Refraction 1.676 InChIKey GIEHIZKCIZLXLF-UHFFFAOYSA-N Storage condition 2-8℃ |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (7-Chloro-4-(4-(4-chlorophenyl)sulfonyl)-1- piperazinyl)quinoline) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (7-Chloro-4-(4-(4-chlorophenyl)sulfonyl)-1- piperazinyl)quinoline) International air transport hazard regulations: Toxic solid, organic, n.o.s. (7-Chloro-4-(4-(4-chlorophenyl)sulfonyl)-1-piperazinyl)quinoline) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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