| Chemical & Physical Properties | |
|---|---|
| CAS Number | 23599-69-1 |
| Catalog No. | 2A-2189687 |
| Chinese Name | 去甲异波尔定 |
| Synonyms | Laurelliptin; norisobolidine<misnomer>; (6aS)-2,10-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,9-diol |
| Molecular Formula | C18H19NO4 |
| Molecular Weight | 313.35 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 553.0±50.0 °C at 760 mmHg |
| Storage Condition | 2-8C |
| Application | Norisoboldine is an isoquinoline alkaloid that is an AhR agonist and can enhance the activity of adenosine A1 receptors. |
| HTC | 2933990090 |
| PubChem ID | 90317187 |
| MDL Number | MFCD09953815 |
| SMILES | COc1cc2c(cc1O)CC1NCCc3cc(OC)c(O)c-2c31 |
| InChI | InChI=1S/C18H19NO4/c1-22-14-8-11-10(6-13(14)20)5-12-16-9(3-4-19-12)7-15(23-2)18(21)17(11)16/h6-8,12,19-21H,3-5H2,1-2H3/t12-/m0/s1 |
| InChI Key | HORZNQYQXBFWNZ-LBPRGKRZSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Use of | Norisoboldine is an isoquinoline alkaloid which acts as an AhR agonist, and enhances the function of the adenosine A1 receptor. Properties Name norisoboldine Synonym More Synonyms Norisoboldine Biological Activity Description Norisoboldine is an isoquinoline alkaloid which acts as an AhR agonist, and enhances the function of the adenosine A1 receptor. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor References [1]. Gao S, et al. Norisoboldine, an alkaloid from Radix linderae, inhibits NFAT activation and attenuates 2,4-dinitrofluorobenzene-induced dermatitis in mice. Immunopharmacol Immunotoxicol. 2016 Oct;38(5):327-33 [2]. Tong B, et al. Norisoboldine, an isoquinoline alkaloid, acts as an aryl hydrocarbon receptor ligand to induce intestinal Treg cells and thereby attenuate arthritis. Int J Biochem Cell Biol. 2016 Jun;75:63-73 [3]. Lv Q, et al. Norisoboldine ameliorates DSS-induced ulcerative colitis in mice through induction of regulatory T cells in colons. Int Immunopharmacol. 2015 Dec;29(2):787-97 [4]. Wei ZF, et al. Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner. Int J Biol Sci. 2015 Jul 17;11(9):1113-26 [5]. Gao X, et al. Norisoboldine attenuates inflammatory pain via the adenosine A1 receptor. Eur J Pain. 2014 Aug;18(7):939-48 Chemical & Physical Properties Molecular Formula C18H19NO4 Exact Mass 313.131409 PSA 70.95000 Index of Refraction 1.643 InChIKey HORZNQYQXBFWNZ-LBPRGKRZSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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