CAS Number343-27-1
Synonyms7-Methoxy-1-methyl-9H-β-carbolinhydrochlorid; 7-Methoxy-1-methyl-9H-β-carboline hydrochloride; Harmine.HCL; EINECS 206-443-8; Harmine hydrochloride hydrate; Harmine monohydrochloride; MFCD00012641; 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, monohydrochloride; HARMINE HYDROCHLORIDE; 7-Methoxy-1-methyl-9H-β-carboline hydrochloride (1:1); 7-Méthoxy-1-méthyl-9H-β-carboline chlorhydrate; 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, hydrochloride (1:1); Banisterine Hydrochloride
Molecular FormulaC13H13ClN2O
Molecular Weight248.71
Boiling Point421.4ºC at 760mmHg
Melting Point265-270°C
AppearanceYellow to slightly green crystalline powder
EINECS206-443-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 343-27-1 |
| Catalog No. | 2A-2189673 |
| Chinese Name | 盐酸去氢骆驼蓬碱 |
| Synonyms | 7-Methoxy-1-methyl-9H-β-carbolinhydrochlorid; 7-Methoxy-1-methyl-9H-β-carboline hydrochloride; Harmine.HCL; EINECS 206-443-8; Harmine hydrochloride hydrate; Harmine monohydrochloride; MFCD00012641; 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, monohydrochloride; HARMINE HYDROCHLORIDE; 7-Methoxy-1-methyl-9H-β-carboline hydrochloride (1:1); 7-Méthoxy-1-méthyl-9H-β-carboline chlorhydrate; 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, hydrochloride (1:1); Banisterine Hydrochloride |
| Molecular Formula | C13H13ClN2O |
| Molecular Weight | 248.71 |
| Boiling Point | 421.4ºC at 760mmHg |
| Melting Point | 265-270°C |
| Appearance | Yellow to slightly green crystalline powder |
| Storage Condition | The warehouse is low-temperature, ventilated, dry, |
| Packaging | III |
| Application | Harmine Hydrochloride (Telepathine Hydrochloride) is a natural bispecific tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine Hydrochlo |
| EINECS | 206-443-8 |
| HTC | 2933990090 |
| PubChem ID | 329825025 |
| MDL Number | MFCD00012641 |
| SMILES | [H+].[Cl-].COc1ccc2c([nH]c3c(C)nccc23)c1 |
| InChI | InChI=1S/C13H12N2O.ClH/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;/h3-7,15H,1-2H3;1H |
| InChI Key | InChIKey=VNPLYCKZIUTKJM-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352205 |
| Hazard Symbols | 6.1(b) |
| Bioactivity | Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Target Ki: 397 nM (5-HT2A serotonin receptor)[1], DYRK1A[2] In Vitro Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM[2]. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine[3]. In Vivo It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group[4]. References [1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91. Chemical & Physical Properties Boiling Point 421.4ºC at 760mmHg Melting Point 265-270°C Molecular Formula C13H13ClN2O Molecular Weight 248.708 Flash Point 139.8ºC Exact Mass 248.071640 PSA 37.91000 LogP 3.83510 |
| Use of | Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1]. Properties Name 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride Synonym More Synonyms Harmine hydrochloride Biological Activity Description Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Ki: 397 nM (5-HT2A serotonin receptor)[1], DYRK1A[2] In Vivo It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group[4]. References [1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91. Chemical & Physical Properties Exact Mass 248.071640 PSA 37.91000 LogP 3.83510 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 1544 Formal shipping name: Alkaloid, solid, not otherwise specified Packing grade: III |
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