CAS Number113-59-7
SynonymsRo 4-0403; Tarasan; (Z)-chlorprothixene; Truxaletten; Chlorprothixene; (3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine; chloroprothixene; CPX; (Z)-2-Chloro-9-(ω-dimethylaminopropylidene)thioxanthene; (Z)-2-Chloro-9-(3'-dimethylaminopropylidene)thioxanthene; Paxyl; Truxil; (Z)-2-Chloro-N,N-dimethylthioxanthene-D9,g-propylamine; (Z)-a-2-Chloro-10-(3-dimethylaminopropylidene)thiaxanthene; Taractan; EINECS 204-032-8; Truxal; (3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine; mk184; n714
Molecular FormulaC18H18ClNS
Molecular Weight315.86
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point435.0±45.0 °C at 760 mmHg
Melting Point97-98°
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 113-59-7 |
| Catalog No. | 2A-9018900 |
| Chinese Name | 氯普噻吨 |
| Synonyms | Ro 4-0403; Tarasan; (Z)-chlorprothixene; Truxaletten; Chlorprothixene; (3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine; chloroprothixene; CPX; (Z)-2-Chloro-9-(ω-dimethylaminopropylidene)thioxanthene; (Z)-2-Chloro-9-(3'-dimethylaminopropylidene)thioxanthene; Paxyl; Truxil; (Z)-2-Chloro-N,N-dimethylthioxanthene-D9,g-propylamine; (Z)-a-2-Chloro-10-(3-dimethylaminopropylidene)thiaxanthene; Taractan; EINECS 204-032-8; Truxal; (3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine; mk184; n714 |
| Molecular Formula | C18H18ClNS |
| Molecular Weight | 315.86 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 435.0±45.0 °C at 760 mmHg |
| Melting Point | 97-98° |
| Storage Condition | -20°C |
| Application | Chlorprothixene has a high affinity for dopamine and histamine receptors, with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM for D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7 res |
| HTC | 2932999099 |
| SMILES | S1c2c(cc(cc2)Cl)\C(=C/CCN(C)C)\c3c1cccc3 |
| InChI | 1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7- |
| InChI Key | WSPOMRSOLSGNFJ-AUWJEWJLSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/18900_1_113_59_7.pdf |
| Use of | Properties Name chlorprothixene Synonym More Synonyms Chlorprothixene Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. von Coburg, Y., et al., Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett, 2009. 19(2): p. 538-42. [2]. Roth, B.L., et al., Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther, 1994. 268(3): p. 1403-10. [3]. Becker, K.A., et al., Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis. Am J Respir Cell Mol Biol, 2010. 42(6): p. 716-24. Chemical & Physical Properties Exact Mass 315.084839 PSA 28.54000 Index of Refraction 1.683 InChIKey WSPOMRSOLSGNFJ-AUWJEWJLSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Thioxanthene-delta(sup 9),gamma-propylamine, 2-chloro-N,N-dimethyl-, (Z)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C18-H18-Cl-N-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C666 BS IYJ FG IU3N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,596,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,252,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50100 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56200 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,373,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,33,1969 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : male 15 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - impotence REFERENCE : AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 120,1004,1964 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974 Safety Information Hazard Codes Xi HS Code 2932999099 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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