CAS Number114-80-7
SynonymsNeostigmin; stigmanolbromide; Prostigmi; Vagostigmine bromide; Neoesserin; Prostigmin bromide; stigmosanbromide; 3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide,Prostigmine; (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide; neoserinebromide; MFCD00011795; prostigmin; Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (1:1); EINECS 204-054-8; Vagostigmin bromide; 3-[(Dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium bromide; (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate; PROSTIGMINE; 3-Dimethylcarbamoyloxy-tri-N-methyl-anilinium,Bromid; 3-((Dimethylcarbamoyl)oxy)-N,N,N-trimethylbenzenaminium bromide; Juvastigmin; 3-dimethylcarbamoyloxy-tri-N-methyl-anilinium,bromide; eustigminbromide; Neostigmine Bromide; Neostigmine (Bromide)
Molecular FormulaC12H19BrN2O2
Molecular Weight303.20
Purity≥98 (HPLC and titration)%
Melting Point175-177 °C (lit.)
Appearancepowder
EINECS204-054-8
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 114-80-7 |
| Catalog No. | 2A-9018911 |
| Chinese Name | 溴化新斯的明 |
| Synonyms | Neostigmin; stigmanolbromide; Prostigmi; Vagostigmine bromide; Neoesserin; Prostigmin bromide; stigmosanbromide; 3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide,Prostigmine; (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide; neoserinebromide; MFCD00011795; prostigmin; Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (1:1); EINECS 204-054-8; Vagostigmin bromide; 3-[(Dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium bromide; (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate; PROSTIGMINE; 3-Dimethylcarbamoyloxy-tri-N-methyl-anilinium,Bromid; 3-((Dimethylcarbamoyl)oxy)-N,N,N-trimethylbenzenaminium bromide; Juvastigmin; 3-dimethylcarbamoyloxy-tri-N-methyl-anilinium,bromide; eustigminbromide; Neostigmine Bromide; Neostigmine (Bromide) |
| Molecular Formula | C12H19BrN2O2 |
| Molecular Weight | 303.20 |
| Purity | ≥98 (HPLC and titration) |
| Melting Point | 175-177 °C (lit.) |
| Appearance | powder |
| Water Solubility | 1 g/ mL |
| Storage Condition | The warehouse is low-temperature, ventilated, dry, |
| Packaging | II |
| Application | Neostigmine Bromide is a cholinesterase inhibitor that acts on myasthenia gravis. |
| EINECS | 204-054-8 |
| HTC | 2924299090 |
| PubChem ID | 24277854 |
| MDL Number | MFCD00011795 |
| SMILES | [Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C |
| InChI | 1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1 |
| InChI Key | LULNWZDBKTWDGK-UHFFFAOYSA-M |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/18911_1_114_80_7.pdf |
| Bioactivity | Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis.Target: CholinesteraseNeostigmine is a parasympathomimetic that acts as a reversible acetylcholinesterase inhibitor. Neostigmine enhances excitatory parasympathetic activity by competing with acetylcholine for attachment to acetylcholinesterase at sites of cholinergic transmission and enhancing cholinergic action. Neostigmine is a safe and effective treatment for acute colonic pseudo-obstruction [1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Trevisani, G.T., N.H. Hyman, and J.M. Church, Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction. Dis Colon Rectum, 2000. 43(5): p. 599-603. Chemical & Physical Properties Melting Point 175-177 °C(lit.) Molecular Formula C12H19BrN2O2 Molecular Weight 303.195 Exact Mass 302.062988 PSA 29.54000 InChIKey LULNWZDBKTWDGK-UHFFFAOYSA-M SMILES CN(C)C(=O)Oc1cccc([N+](C)(C)C)c1.[Br-] Water Solubility 1 g/ mL |
| Use of | Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis.Target: CholinesteraseNeostigmine is a parasympathomimetic that acts as a reversible acetylcholinesterase inhibitor. Neostigmine enhances excitatory parasympathetic activity by competing with acetylcholine for attachment to acetylcholinesterase at sites of cholinergic transmission and enhancing cholinergic action. Neostigmine is a safe and effective treatment for acute colonic pseudo-obstruction [1]. Properties Articles37 Name neostigmine bromide Synonym More Synonyms Neostigmine Bromide Biological Activity Description Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis.Target: CholinesteraseNeostigmine is a parasympathomimetic that acts as a reversible acetylcholinesterase inhibitor. Neostigmine enhances excitatory parasympathetic activity by competing with acetylcholine for attachment to acetylcholinesterase at sites of cholinergic transmission and enhancing cholinergic action. Neostigmine is a safe and effective treatment for acute colonic pseudo-obstruction [1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Trevisani, G.T., N.H. Hyman, and J.M. Church, Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction. Dis Colon Rectum, 2000. 43(5): p. 599-603. Chemical & Physical Properties Molecular Formula C12H19BrN2O2 Exact Mass 302.062988 PSA 29.54000 InChIKey LULNWZDBKTWDGK-UHFFFAOYSA-M |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Neostigminbromid) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Neostigminbromid) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Neostigminbromid) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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