CAS Number76721-89-6
SynonymsDL-[N-(3-mercapto-2-benzylpropanoyl)]glycine; Glycine,N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-,(+-); N-[(R,S)-3-mercapto-2-benzyl-propionyl]glycine; DL-Thiorphan; Tiorphan; (2-mercaptomethyl-3-phenyl-propionylamino)-acetic acid; N-(2-Benzyl-3-sulfanylpropanoyl)glycine; DL-3-Mercapto-2-benzylpropanoylglycine; Prestwick_694; N-(3-mercapto-2-benzylpropanoyl)glycine; (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE; (3-Mercapto-2-benzylpropionyl)glycine; Thiorphan
Molecular FormulaC12H15NO3S
Molecular Weight253.32
Purity≥98 (TLC)%
Density1.2±0.1 g/cm3
Boiling Point524.0±50.0 °C at 760 mmHg
Melting Point138 °C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 76721-89-6 |
| Catalog No. | 2A-3178446 |
| Chinese Name | 3-巯基-2苄基丙基甘氨酸 |
| Synonyms | DL-[N-(3-mercapto-2-benzylpropanoyl)]glycine; Glycine,N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-,(+-); N-[(R,S)-3-mercapto-2-benzyl-propionyl]glycine; DL-Thiorphan; Tiorphan; (2-mercaptomethyl-3-phenyl-propionylamino)-acetic acid; N-(2-Benzyl-3-sulfanylpropanoyl)glycine; DL-3-Mercapto-2-benzylpropanoylglycine; Prestwick_694; N-(3-mercapto-2-benzylpropanoyl)glycine; (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE; (3-Mercapto-2-benzylpropionyl)glycine; Thiorphan |
| Molecular Formula | C12H15NO3S |
| Molecular Weight | 253.32 |
| Purity | ≥98 (TLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 524.0±50.0 °C at 760 mmHg |
| Melting Point | 138 °C |
| Appearance | powder |
| Storage Condition | room temperature |
| Application | Thiophene is a selective NEP (Nepallysin) inhibitor with an IC50 of 6.9 nM [1]. |
| HTC | 2930909090 |
| PubChem ID | 24278747 |
| MDL Number | MFCD00058435 |
| SMILES | OC(=O)CNC(=O)C(CS)Cc1ccccc1 |
| InChI | 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) |
| InChI Key | LJJKNPQAGWVLDQ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 4872101 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/179099_1_76721_89_6.pdf |
| Use of | Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[1]. Properties Articles31 Name 2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid Synonym More Synonyms Thiorphan Biological Activity Description Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[1]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin References [1]. Whyteside AR, Turner AJ. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582(16):2382-6. Chemical & Physical Properties Molecular Formula C12H15NO3S Exact Mass 253.077271 PSA 105.20000 Index of Refraction 1.577 InChIKey LJJKNPQAGWVLDQ-UHFFFAOYSA-N Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2930909090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2930909090. other organo-sulfur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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