CAS Number452342-67-5
SynonymsN-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide; 4-{4-[5-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl}-N-(tetrahydro-2H-pyran-4-yl)benzamide; 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide; GW788388
Molecular FormulaC25H23O2N5
Molecular Weight425.49
Density1.3±0.1 g/cm3
Boiling Point683.2±55.0 °C at 760 mmHg
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 452342-67-5 |
| Catalog No. | 2A-1175001 |
| Chinese Name | 4-[4-[3-(吡啶-2-基)-1H-吡唑-4-基]吡啶-2-基]-N-(四氢吡喃-4-基)苯甲酰胺 |
| Synonyms | N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide; 4-{4-[5-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl}-N-(tetrahydro-2H-pyran-4-yl)benzamide; 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide; GW788388 |
| Molecular Formula | C25H23O2N5 |
| Molecular Weight | 425.49 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 683.2±55.0 °C at 760 mmHg |
| Appearance | white solid |
| Storage Condition | -20℃ |
| Application | GW788388 is a potent ALK5 inhibitor with an IC50 value of 18 nM; it simultaneously inhibits the activities of TGF-β type II receptors and activin type II receptors, but has no effect on BMP type II re |
| HTC | 2934999090 |
| PubChem ID | 15200776 |
| MDL Number | MFCD16038936 |
| SMILES | O=C(NC1CCOCC1)c1ccc(-c2cc(-c3cn[nH]c3-c3ccccn3)ccn2)cc1 |
| InChI | InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31) |
| InChI Key | SAGZIBJAQGBRQA-UHFFFAOYSA-N |
| MSDS | msds/175395_1_452342_67_5.pdf |
| Use of | GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor. Properties Name 4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide Synonym More Synonyms GW788388 Biological Activity Description GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor. Related Catalog Signaling Pathways >> TGF-beta/Smad >> TGF-β Receptor Research Areas >> Cancer IC50: 18 nM (ALK5) References [1]. Petersen M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int, 2008, 73(6), 705-715. [2]. Tan SM, et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol, 2010, 298(5), H1415-1425. [3]. Gellibert F, et al. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor. J Med Chem. 2006, 49 Chemical & Physical Properties Molecular Formula C25H23N5O2 Exact Mass 425.185181 PSA 92.79000 Appearance of Characters white solid Index of Refraction 1.680 InChIKey SAGZIBJAQGBRQA-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| JTT-705 | 211513-37-0 | 2A-1174993 |
| INNO-206 HCl salt/INNO206 HCl salt | 480998-12-7 | 2A-1174994 |
| PF-04929113 | 908115-27-5 | 2A-1174998 |
| A66 | 1166227-08-2 | 2A-1174999 |
| OMecaMtiv Mecarbil | 873697-71-3 | 2A-1175000 |
| CCT 137690 | 1095382-05-0 | 2A-1175002 |
| N/A | 929016-96-6 | 2A-1175003 |
| GDC-0068 | 1001264-89-6 | 2A-1175004 |
| AG 490 | 133550-30-8 | 2A-1175006 |
| WP1130 | 856243-80-6 | 2A-1175007 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS