| Chemical & Physical Properties | |
|---|---|
| CAS Number | 937272-79-2 |
| Catalog No. | 2A-1170978 |
| Chinese Name | 帕西替尼(SB1518) |
| Synonyms | SB1518; Pacritinib |
| Molecular Formula | C28H32N4O3 |
| Molecular Weight | 472.579 |
| Purity | 98% |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 711.4±70.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Pacritinib is a potent inhibitor of wild-type JAK2 and JAK2V617F mutant, with IC50 of 23 nM and 19 nM, respectively. Pacritinib also inhibits FLT3 and its mutant FLT3D835Y with IC50 of 22 nM and 6 nM, |
| PubChem ID | 85739036 |
| SMILES | C1=CCOCc2cc(ccc2OCCN2CCCC2)Nc2nccc(n2)-c2cccc(c2)COC1 |
| InChI | InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+ |
| InChI Key | HWXVIOGONBBTBY-ONEGZZNKSA-N |
| Transport Info | Product name: Paxitinib (SB1518) |
| Related Products in Specialty Chemicals | ||
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| GDC-0810(ARN-810) | 1365888-06-7 | 2A-1170972 |
| AZD 3759 | 1626387-80-1 | 2A-1170973 |
| MP-412 | 451492-95-8 | 2A-1170974 |
| 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-Methoxyphenyl)Methyl]- | 924909-16-0 | 2A-1170976 |
| PD 0332991 HCl | 827022-32-2 | 2A-1170977 |
| IDO inhibitor 1 | 1204669-37-3 | 2A-1170979 |
| Elafibranor(GFT505) | 923978-27-2 | 2A-1170983 |
| MK-8931 | 1286770-55-5 | 2A-1170984 |
| GX-674 | 1432913-36-4 | 2A-1170985 |
| Fevipiprant | 872365-14-5 | 2A-1170986 |
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