| Chemical & Physical Properties | |
|---|---|
| CAS Number | 868540-17-4 |
| Catalog No. | 2A-1170956 |
| Chinese Name | 卡非佐米 |
| Synonyms | PX-171-007; Kyprolis; UNII-72X6E3J5AR; Carfilzomib (PR-171); Carfilzomib; PR-171; PR171 |
| Molecular Formula | C40H57N5O7 |
| Molecular Weight | 719.910 |
| Purity | 98% |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 975.6±65.0 °C at 760 mmHg |
| Melting Point | 204-208°C |
| Storage Condition | -20°C |
| Application | Carfilzomib is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells. |
| HTC | 2933790090 |
| PubChem ID | 16658822 |
| SMILES | CC(C)CC(NC(=O)C(CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)C1(C)CO1 |
| InChI | InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1 |
| InChI Key | BLMPQMFVWMYDKT-NZTKNTHTSA-N |
| Use of | Properties Name carfilzomib Synonym More Synonyms Carfilzomib Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Cancer IC50: 5 nM (Proteasome) Cell Assay WST-1 is used to determine the effects of proteasome inhibitors on cell proliferation according to the manufacturer's protocol. The inhibition of proliferation is calculated in relation to parallel control cells that receive vehicle alone and tabulated in KaleidaGraph 3.0.1 or Excel 2000. A linear spline function is used to interpolate the median inhibitory concentration (IC50) using XLfit 4 software. The degree of resistance (DOR) is calculated using the formula: DOR=IC50(resistant cells)/IC50(sensitive cells). References [1]. Kuhn DJ, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood. 2007 Nov 1;110(9):3281-90. [2]. Dasmahapatra G, et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Mol Cancer Ther. 2011 Sep;10(9):1686-97. Chemical & Physical Properties Molecular Formula C40H57N5O7 Exact Mass 719.425781 PSA 172.43000 Index of Refraction 1.551 InChIKey BLMPQMFVWMYDKT-NZTKNTHTSA-N Safety Information HS Code 2933790090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Abiraterone Related CoMpound 2 (Prasterone Triflate) | 124643-35-2 | 2A-1170887 |
| Acarbose D-Fructose IMpurity | 1013621-79-8 | 2A-1170890 |
| β-Estradiol 3-acetate | 4245-41-4 | 2A-1170898 |
| OSELTAMIVIR MONO HYDROCHLORIDE | 204255-09-4 | 2A-1170903 |
| Abemaciclib | 1231929-97-7 | 2A-1170937 |
| Entrectinib | 1108743-60-7 | 2A-1170981 |
| Nintedanib Ethanesulfonate Salt | 656247-18-6 | 2A-1170982 |
| BAY 80-6946 (Copanlisib) | 1032568-63-0 | 2A-1170992 |
| Darolutamide | 1297538-32-9 | 2A-1171038 |
| Neratinib Maleate | 915942-22-2 | 2A-1171046 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS