| Chemical & Physical Properties | |
|---|---|
| CAS Number | 327033-36-3 |
| Catalog No. | 2A-1170405 |
| Chinese Name | 5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮 |
| Synonyms | (5E)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione; TCS-PIM-1-4a; (5Z)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione |
| Molecular Formula | C11H6F3NO2S |
| Molecular Weight | 273.231 |
| Density | 1.5±0.1 g/cm3 |
| Storage Condition | 2-8℃ |
| Application | TCS-PIM-1-4a is a Pim inhibitor that can block mTORC1 activity through the activation of AMPK and has killing activity against various bone marrow and lymphocyte lines, with IC50 ranging from 0.8 to 4 |
| HTC | 2934999090 |
| PubChem ID | 3381866 |
| SMILES | O=C1NC(=O)C(=Cc2cccc(C(F)(F)F)c2)S1 |
| InChI | InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5+ |
| InChI Key | NGJLOFCOEOHFKQ-VMPITWQZSA-N |
| Use of | Properties Name SMI-4a Synonym More Synonyms TCS-PIM-1-4a Biological Activity Related Catalog Signaling Pathways >> JAK/STAT Signaling >> Pim Research Areas >> Cancer References [1]. Lin YW, Beharry ZM, Hill EG, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33. [2]. Beharry Z, Mahajan S, Zemskova M,et al. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011;108(2):528-33. [3]. Benoit SR, Ji M, Fleming R,et al . Predictors of dropouts from a San Diego diabetes program: a case control study. Prev Chronic Dis. 2004:1(4):A10. [4]. Zuping Xia, Christian Knaak, Jian Ma et al. Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases. J. Med. Chem., 2009, 52 (1), pp 74-86 Chemical & Physical Properties Molecular Formula C11H6F3NO2S Exact Mass 273.007141 PSA 71.47000 Index of Refraction 1.602 InChIKey NGJLOFCOEOHFKQ-VMPITWQZSA-N Storage condition 2-8℃ Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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