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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 5-{[(2S,5R)-2,5-dimethyl-4-(tetrahydro-2H-pyran-4-ylmethyl)piperazin-1-yl]carbonyl}-N-(5-fluoro-2-methylpyrimidin-4-yl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine
5-{[(2S,5R)-2,5-dimethyl-4-(tetrahydro-2H-pyran-4-ylmethyl)piperazin-1-yl]carbonyl}-N-(5-fluoro-2-methylpyrimidin-4-yl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine structure, CAS 1046787-18-1

5-{[(2S,5R)-2,5-dimethyl-4-(tetrahydro-2H-pyran-4-ylmethyl)piperazin-1-yl]carbonyl}-N-(5-fluoro-2-methylpyrimidin-4-yl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine

CAS Number1046787-18-1

SynonymsMFCD28900747

Molecular FormulaC25H37FN8O2

Molecular Weight500.612

Purity

Density1.3±0.1 g/cm3

Boiling Point622.8±55.0 °C at 760 mmHg

Melting Point

Flash Point

Appearance

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Cat. No.: 2A-1170339 Purity:
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Quality Control of [ 1046787-18-1 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1046787-18-1
Catalog No.2A-1170339
Chinese NamePKC-IN-1
SynonymsMFCD28900747
Molecular FormulaC25H37FN8O2
Molecular Weight500.612
Density1.3±0.1 g/cm3
Boiling Point622.8±55.0 °C at 760 mmHg
Storage Condition2-8℃
ApplicationPKC-IN-1 is a potent, ATP-competitive, reversible PKC inhibitor with Ki values of 5.3 and 10.4 nM for human PKCβ and PKCα, respectively, and IC50 values for human PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC
PubChem ID57249754
SMILESCc1ncc(F)c(Nc2n[nH]c3c2CN(C(=O)N2CC(C)N(CC4CCOCC4)CC2C)C3(C)C)n1
InChIInChI=1S/C25H37FN8O2/c1-15-12-33(16(2)11-32(15)13-18-6-8-36-9-7-18)24(35)34-14-19-21(25(34,4)5)30-31-22(19)29-23-20(26)10-27-17(3)28-23/h10,15-16,18H,6-9,11-14H2,1-5H3,(H2,27,28,29,30,31)/t15-,16+/m1/s1
InChI KeyDKXZBPBWIGORKP-CVEARBPZSA-N
Transport InfoProduct name: PKC-IN-1
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