| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1165910-22-4 |
| Catalog No. | 2A-1170371 |
| Chinese Name | 4-((R)-2-((R)-2,2,2-三氟-1-羟乙基)呲咯烷-1)-2-三氟甲基苯腈 |
| Synonyms | 4-{(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl}-2-(trifluoromethyl)benzonitrile; LGD-4033; Lingandro; LGD4033 |
| Molecular Formula | C14H12F6N2O |
| Molecular Weight | 338.248 |
| Purity | 98% |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 439.9±45.0 °C at 760 mmHg |
| Storage Condition | -20℃ |
| Application | LGD-4033 is a novel non-steroidal, oral SARM that binds to the androgen receptor with high affinity (Ki of 1 nM) and selectivity. |
| HTC | 2933990090 |
| PubChem ID | 85093428 |
| SMILES | N#Cc1ccc(N2CCCC2C(O)C(F)(F)F)cc1C(F)(F)F |
| InChI | InChI=1S/C14H12F6N2O/c15-13(16,17)10-6-9(4-3-8(10)7-21)22-5-1-2-11(22)12(23)14(18,19)20/h3-4,6,11-12,23H,1-2,5H2/t11-,12-/m1/s1 |
| InChI Key | OPSIVAKKLQRWKC-VXGBXAGGSA-N |
| Use of | LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity.IC50 value: 1 nM (Ki, for androgen receptor) Target: androgen receptorin vitro: LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity.in vivo: LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate In animal models. LGD-4033 is well tolerated, has a long elimination half-life and dose-proportional accumulation upon multiple dosing. LGD-4033 is safe, has favorable pharmacokinetic profile, and increases lean body mass even during this short period without change in prostate-specific antigen. Properties Name 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile Synonym More Synonyms LGD-4033 Biological Activity Description LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity.IC50 value: 1 nM (Ki, for androgen receptor) Target: androgen receptorin vitro: LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity.in vivo: LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate In animal models. LGD-4033 is well tolerated, has a long elimination half-life and dose-proportional accumulation upon multiple dosing. LGD-4033 is safe, has favorable pharmacokinetic profile, and increases lean body mass even during this short period without change in prostate-specific antigen. Related Catalog Signaling Pathways >> Others >> Androgen Receptor Research Areas >> Endocrinology References [1]. Basaria S,et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):87-95. Chemical & Physical Properties Molecular Formula C14H12F6N2O Exact Mass 338.085388 PSA 47.26000 Index of Refraction 1.496 InChIKey OPSIVAKKLQRWKC-VXGBXAGGSA-N Storage condition -20℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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