| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67953-08-6 |
| Catalog No. | 2A-1170027 |
| Chinese Name | L-谷氨酸γ-(p-硝基苯胺)盐酸盐 |
| Synonyms | L-GLUTAMIC ACID γ-(P-NITROANILIDE) HYDROCHLORIDE |
| Molecular Formula | C11H14ClN3O5 |
| Molecular Weight | 303.69900 |
| Purity | 98.00 |
| Boiling Point | 590.6ºC at 760 mmHg |
| Storage Condition | 2-8°C, inert gas storage |
| Application | GPNA hydrochloride is a well-known substrate of gamma-glutamyl transferase (GGT). GPNA hydrochloride is a specific inhibitor of the glutamine (Gln) transporter ASCT2. GPNA hydrochloride also inhibits |
| PubChem ID | 14800617 |
| SMILES | Cl.NC(CCC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)O |
| InChI | InChI=1S/C11H13N3O5.ClH/c12-10(15)6-5-9(11(16)17)13-7-1-3-8(4-2-7)14(18)19;/h1-4,9,13H,5-6H2,(H2,12,15)(H,16,17);1H |
| InChI Key | OJEVFSFTVARWQX-FVGYRXGTSA-N |
| Hazard Symbols | transportation |
| Bioactivity | GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Target ASCT2[1] In Vitro GPNA (10-1000 μM; 48 hours) induces a dose-dependent decrease of cell viability in A549 cells[1]. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 10, 100, 250, 500 , and 1000 μM Incubation Time: 48 hours Result: Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250 μM. References [1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891. Chemical & Physical Properties Boiling Point 590.6ºC at 760 mmHg Molecular Formula C11H14ClN3O5 Molecular Weight 303.69900 Flash Point 311ºC Exact Mass 303.06200 PSA 138.24000 LogP 2.82390 InChIKey OJEVFSFTVARWQX-FVGYRXGTSA-N SMILES Cl.NC(CCC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)O |
| Use of | Properties Articles26 Name L-Glutamic acid γ-(p-nitroanilide) hydrochloride Synonym More Synonyms GPNA hydrochloride Biological Activity Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891. Chemical & Physical Properties Exact Mass 303.06200 PSA 138.24000 LogP 2.82390 InChIKey OJEVFSFTVARWQX-FVGYRXGTSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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