CAS Number68-22-4
SynonymsMini-Pe; Noriday; Ethynylnortestosterone; Utovlan; sc4640; Anovule; MFCD00067596; (17a)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one; 19-Nor-17a-ethynyl-17b-hydroxy-4-androsten-3-one; 19-nor-17α-Ethynylandrosten-17β-ol-3-one; Menzol; ENT; 17α-Ethynyl-17β-hydroxyestr-4-en-3-one; 19-nor-17α-Ethynyl-17β-hydroxy-4-androsten-3-one; Norethindrone; Primolut N; (17b)-17-ethynyl-17-hydroxyestr-4-en-3-one; Ethinylnortestosterone; Norfor; 17a-Ethynyl-19-nortestosterone; (17α)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one; 19-Nor-17α-ethynyltestosterone; Norgestin; 17-Hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one; 19-Nor-17a-ethynyltestosterone; EINECS 200-681-6; 17α-Ethynyl-17-hydroxy-4-estren-3-one; 19-Nor-17-ethinyl testosterone; Triella; 19-Nor-17a-ethynylandrosten-17b-ol-3-one
Molecular FormulaC20H26O2
Molecular Weight298.42
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point447.0±45.0 °C at 760 mmHg
Melting Point205-206 °C(lit.)
AppearanceOff-white to light yellow solid
EINECS200-681-6
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68-22-4 |
| Catalog No. | 2A-9016970 |
| Chinese Name | 炔诺酮 |
| Synonyms | Mini-Pe; Noriday; Ethynylnortestosterone; Utovlan; sc4640; Anovule; MFCD00067596; (17a)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one; 19-Nor-17a-ethynyl-17b-hydroxy-4-androsten-3-one; 19-nor-17α-Ethynylandrosten-17β-ol-3-one; Menzol; ENT; 17α-Ethynyl-17β-hydroxyestr-4-en-3-one; 19-nor-17α-Ethynyl-17β-hydroxy-4-androsten-3-one; Norethindrone; Primolut N; (17b)-17-ethynyl-17-hydroxyestr-4-en-3-one; Ethinylnortestosterone; Norfor; 17a-Ethynyl-19-nortestosterone; (17α)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one; 19-Nor-17α-ethynyltestosterone; Norgestin; 17-Hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one; 19-Nor-17a-ethynyltestosterone; EINECS 200-681-6; 17α-Ethynyl-17-hydroxy-4-estren-3-one; 19-Nor-17-ethinyl testosterone; Triella; 19-Nor-17a-ethynylandrosten-17b-ol-3-one |
| Molecular Formula | C20H26O2 |
| Molecular Weight | 298.42 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 447.0±45.0 °C at 760 mmHg |
| Melting Point | 205-206 °C(lit.) |
| Appearance | Off-white to light yellow solid |
| Water Solubility | chloroform: ≥50 mg/mL, clear, colorless |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Norethindrone is an FDA-approved progestin for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea in women. |
| EINECS | 200-681-6 |
| HTC | 2937290090 |
| PubChem ID | 329823570 |
| MDL Number | MFCD00067596 |
| SMILES | O[C@@]1([C@@]2([C@H]([C@H]3[C@@H]([C@H]4CCC(=O)C=C4CC3)CC2)CC1)C)C#C |
| InChI | 1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1 |
| InChI Key | VIKNJXKGJWUCNN-XGXHKTLJSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/16970_1_68_22_4.pdf |
| Bioactivity | Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Related Catalog Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology Target Progesterone Receptor[1] In Vivo Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief[1]. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back[2]. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, behavioral changes, or organ pathology[3]. Norethindrone acetate administration leads to significant and proportional reductions of the concentrations of triglycerides, cholesterol and phospholipids of plasma lipoproteins of density <1.006 of rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides of isolated hepatocytes from fed rats[4]. Animal Admin Rats: Female Sprague-Dawley rats (200-210 g), 6 of which serve as controls, are individually caged in an animal room illuminated from 9:00 a.m. to 9:00 p.m. Each of the 7 rats receiving norethindrone acetate is fed 35 μg/day for 2 weeks. Water and the rat chow which is high in carbohydrate are available ad libitum[4]. References [1]. Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43(1):24-7. [2]. Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25(2):105-8. [3]. Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 Aug;34(1):53-61. [4]. Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 Jan;46(1):41-8. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 447.0±45.0 °C at 760 mmHg Melting Point 205-206 °C(lit.) Molecular Formula C20H26O2 Molecular Weight 298.419 Flash Point 190.5±21.3 °C Exact Mass 298.193268 PSA 37.30000 LogP 3.38 Vapour Pressure 0.0±2.5 mmHg at 25°C Index of Refraction 1.577 InChIKey VIKNJXKGJWUCNN-XGXHKTLJSA-N SMILES C#CC1(O)CCC2C3CCC4=CC(=O)CCC4C3CCC21C Storage condition -20°C Freezer Water Solubility chloroform: ≥50 mg/mL, clear, colorless |
| Use of | Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Properties Articles60 Name norethisterone Synonym More Synonyms Norethindrone Biological Activity Description Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Related Catalog Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology Progesterone Receptor[1] References [1]. Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43(1):24-7. [2]. Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25(2):105-8. [3]. Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 Aug;34(1):53-61. [4]. Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 Jan;46(1):41-8. Chemical & Physical Properties Molecular Formula C20H26O2 Exact Mass 298.193268 PSA 37.30000 Index of Refraction 1.577 InChIKey VIKNJXKGJWUCNN-XGXHKTLJSA-N |
| Transport Info | Product Name: Norethindrone |
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