| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1001645-58-4 |
| Catalog No. | 2A-1169374 |
| Chinese Name | SRT1720 HCl |
| Synonyms | SRT1720; SRT-1720,SRT 1720; QCR-61; SRT 1720 Hydrochloride; cc-265; CS-0509; S1129_Selleck; SRT 1720; SRT 1720 (Hydrochloride) |
| Molecular Formula | C25H23N7OS.xHCl |
| Molecular Weight | 506.022 |
| Purity | 98.00 |
| Density | 1.58 |
| Storage Condition | Room temperature, dry, sealed |
| Application | SRT 1720 Hydrochloride is a selective SIRT1 activator with an EC1.5 of 0.16 μM and a weak effect on SIRT2 and SIRT3 with EC1.5 values of 37 μM and 300 μM respectively. |
| HTC | 2934100090 |
| PubChem ID | 57584664 |
| SMILES | Cl.O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1 |
| InChI | InChI=1S/C25H23N7OS.ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);1H |
| InChI Key | DTGRRMPPXCRRIM-UHFFFAOYSA-N |
| Use of | SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities on SIRT2 and SIRT3 with EC1.5s of 37 μM and 300 μM, respectively. Properties Name N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide,hydrochloride Synonym More Synonyms SRT1720 HCl Biological Activity Description SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities on SIRT2 and SIRT3 with EC1.5s of 37 μM and 300 μM, respectively. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Metabolic Disease SIRT1:0.16 μM (EC1.5) SIRT2:37 μM (EC1.5) In Vitro SRT1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300[2]. References [1]. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 [2]. Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan?,Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61 [3]. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45. [4]. Gao D, et al. Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. Hypertension. 2016 Nov;68(5):1191-1199. Chemical & Physical Properties Molecular Formula C25H23N7OS.xHCl Exact Mass 505.145142 PSA 115.69000 LogP 4.80520 InChIKey DTGRRMPPXCRRIM-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2934100090 |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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