CAS Number9072-19-9
SynonymsMFCD00131109; (2ξ,6S)-2,6-Anhydro-1-deoxy-6-methyl-5-O-sulfo-D-arabino-hexitol; [(2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyl-tetrahydropyran-3-yl] hydrogen sulfate; (2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate
Molecular FormulaC7H14O7S
Molecular Weight242.24700
Purity85%%
AppearanceWhite to light yellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 9072-19-9 |
| Catalog No. | 2A-1169378 |
| Chinese Name | 岩藻多糖 |
| Synonyms | MFCD00131109; (2ξ,6S)-2,6-Anhydro-1-deoxy-6-methyl-5-O-sulfo-D-arabino-hexitol; [(2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyl-tetrahydropyran-3-yl] hydrogen sulfate; (2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate |
| Molecular Formula | C7H14O7S |
| Molecular Weight | 242.24700 |
| Purity | 85% |
| Appearance | White to light yellow powder |
| Storage Condition | Store airtight in a cool, dry warehouse. |
| Application | Fucoidan is a biologically active polysaccharide and an effective inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and anti-fatigue activities[1]. |
| MSDS | msds/169481_2_9072_19_9.pdf |
| Bioactivity | Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1]. Related Catalog Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease In Vitro Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae[1]. Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC50 of 0.12-4.64 mg/mL[1]. Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress[2]. In Vivo Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth and metastasis[3]. Animal Model: Mice[3] Dosage: 10-400 mg/kg Administration: Intraperitoneal injection; followed by total-body irradiation Result: The mice injected with 100 mg/kg showed the best survival rate at 30 days post-irradiation. References [1]. Kyung-Tae Kim, et al. Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum.Phytochemistry. 2014 Feb;98:27-33. [2]. Zeinab El Rashed, et al. Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources. Molecules. 2021 Jul 24;26(15):4467. [3]. Farzaneh Atashrazm, et al. Fucoidan and cancer: a multifunctional molecule with anti-tumor potential. Mar Drugs. 2015 Apr 14;13(4):2327-46. Chemical & Physical Properties Molecular Formula C7H14O7S Molecular Weight 242.24700 Exact Mass 242.04600 PSA 121.67000 |
| Use of | Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1]. Properties Articles40 Name Fucoidan Synonym More Synonyms Fucoidan Biological Activity Description Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1]. Related Catalog Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease References [1]. Kyung-Tae Kim, et al. Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum.Phytochemistry. 2014 Feb;98:27-33. [2]. Zeinab El Rashed, et al. Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources. Molecules. 2021 Jul 24;26(15):4467. [3]. Farzaneh Atashrazm, et al. Fucoidan and cancer: a multifunctional molecule with anti-tumor potential. Mar Drugs. 2015 Apr 14;13(4):2327-46. Chemical & Physical Properties Molecular Formula C7H14O7S Exact Mass 242.04600 PSA 121.67000 |
| Transport Info | Product name: Fucoidan |
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