CAS Number67-16-3
SynonymsMFCD00010427; Thiamine Disulfide; Vitamin B1 Disulfide; EINECS 200-644-4; Aneurine Disulfide; AKTIVIN
Molecular FormulaC24H34N8O4S2
Molecular Weight562.71
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point886.1±65.0 °C at 760 mmHg
Melting Point177ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67-16-3 |
| Catalog No. | 2A-9016944 |
| Chinese Name | 二硫化硫胺水合物 |
| Synonyms | MFCD00010427; Thiamine Disulfide; Vitamin B1 Disulfide; EINECS 200-644-4; Aneurine Disulfide; AKTIVIN |
| Molecular Formula | C24H34N8O4S2 |
| Molecular Weight | 562.71 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 886.1±65.0 °C at 760 mmHg |
| Melting Point | 177ºC |
| Appearance | powder |
| Storage Condition | Room Temperature |
| Application | Thiamine disulfide is a vitamin B1 derivative and is the oxidized dimer of thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly inhibits HIV-1 transactivator (Tat |
| SMILES | S(S\C(=C(\N(Cc2c(nc(nc2)C)N)C=O)/C)\CCO)\C(=C(\N(Cc1c(nc(nc1)C)N)C=O)/C)\CCO |
| InChI | 1S/C24H34N8O4S2/c1-15(31(13-35)11-19-9-27-17(3)29-23(19)25)21(5-7-33)37-38-22(6-8-34)16(2)32(14-36)12-20-10-28-18(4)30-24(20)26/h9-10,13-14,33-34H,5-8,11-12H2,1-4H3,(H2,25,27,29)(H2,26,28,30)/b21-15+,22-16+ |
| InChI Key | GFEGEDUIIYDMOX-YHARCJFQSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/16944_1_67_16_3.pdf |
| Bioactivity | Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2]. Related Catalog Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Metabolic Disease In Vitro Thiamine disulfide markedly inhibits production of progeny HIV-1 in acute and chronic HIV-1-infected CEM at nontoxic concentrations of 500-1000 μM. Thiamine disulfide (500 μM) blocks 99.7% of HIV-1 production after 96 hours culture in acute HIV-1 (LAV-1) infection, whereas it inhibits 90-98% of HIV-1 production in chronic-infected cells (CEM/LAV-1, H9/MN, and Molt-4/IIIB)[1]. References [1]. S Shoji, et al. Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production. Biochem Biophys Res Commun. 1994 Nov 30;205(1):967-75. [2]. Y Komata, et al. In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. J Pharm Sci. 1992 Aug;81(8):744-6. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 886.1±65.0 °C at 760 mmHg Melting Point 177ºC Molecular Formula C24H34N8O4S2 Molecular Weight 562.708 Flash Point 489.7±34.3 °C Exact Mass 562.214417 PSA 235.28000 LogP 2.79 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.669 InChIKey GFEGEDUIIYDMOX-YHARCJFQSA-N SMILES CC(=C(CCO)SSC(CCO)=C(C)N(C=O)Cc1cnc(C)nc1N)N(C=O)Cc1cnc(C)nc1N |
| Use of | Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2]. Properties Name Thiamine Disulfide Hydrate Synonym More Synonyms Thiamine Disulfide Hydrate Biological Activity Description Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2]. Related Catalog Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Metabolic Disease References [1]. S Shoji, et al. Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production. Biochem Biophys Res Commun. 1994 Nov 30;205(1):967-75. [2]. Y Komata, et al. In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. J Pharm Sci. 1992 Aug;81(8):744-6. Chemical & Physical Properties Molecular Formula C24H34N8O4S2 Exact Mass 562.214417 PSA 235.28000 Index of Refraction 1.669 InChIKey GFEGEDUIIYDMOX-YHARCJFQSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in Nutritional Ingredients | ||
|---|---|---|
| L-Phenylalanine | 63-91-2 | 2A-9016893 |
| Pyridoxine; Vitamin B6 | 65-23-6 | 2A-9016915 |
| 3,5-Diiodo-DL-tyrosine | 66-02-4 | 2A-9016927 |
| Pyridoxal | 66-72-8 | 2A-9016933 |
| Thiamine hydrochloride; Vitamin B1 | 67-03-8 | 2A-9016941 |
| L-Ornithine | 70-26-8 | 2A-9017000 |
| 3-Iodo-L-tyrosine | 70-78-0 | 2A-9017010 |
| Succinylcholine chloride | 71-27-2 | 2A-9017013 |
| L-Valine | 72-18-4 | 2A-9017027 |
| L-Tryptophan | 73-22-3 | 2A-9017037 |
| Browse all Nutritional Ingredients products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS