CAS Number60-18-4
SynonymsL-tyrosine zwitterion; hydrogen L-tyrosinate; MEVINOLIN; LOVALIP; a-Amino-p-hydroxyhydrocinnamic Acid; LOVASTIN; MEVACOR; H-Tyr-OH; Tyrosine; MFCD00002606; L-Tyr; Rovacor; Tyr; (S)-(-)-Tyrosine; Sivlor; L-Tyrosine; (S)-a-Amino-4-hydroxybenzenepropanoic acid; b-(p-Hydroxyphenyl)alanine; mevlor; Tyrosinum [Latin]; (S)-a-amino-4-hydroxy-Benzenepropanoic acid; (S)-tyrosine; (S)-α-amino-4-hydroxy-Benzenepropanoic acid; EINECS 200-460-4; msd803; Paschol
Molecular Formula4-(HO)C6H4CH2CH(NH2)CO2H
Molecular Weight181.19
Purity99.0-101.0%
Density1.3±0.1 g/cm3
Boiling Point385.2±32.0 °C at 760 mmHg
Melting Point>300 °C (dec.) (lit.)
Appearancepowder
EINECS200-460-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 60-18-4 |
| Catalog No. | 2A-9016833 |
| Chinese Name | L-酪氨酸 |
| Synonyms | L-tyrosine zwitterion; hydrogen L-tyrosinate; MEVINOLIN; LOVALIP; a-Amino-p-hydroxyhydrocinnamic Acid; LOVASTIN; MEVACOR; H-Tyr-OH; Tyrosine; MFCD00002606; L-Tyr; Rovacor; Tyr; (S)-(-)-Tyrosine; Sivlor; L-Tyrosine; (S)-a-Amino-4-hydroxybenzenepropanoic acid; b-(p-Hydroxyphenyl)alanine; mevlor; Tyrosinum [Latin]; (S)-a-amino-4-hydroxy-Benzenepropanoic acid; (S)-tyrosine; (S)-α-amino-4-hydroxy-Benzenepropanoic acid; EINECS 200-460-4; msd803; Paschol |
| Molecular Formula | 4-(HO)C6H4CH2CH(NH2)CO2H |
| Molecular Weight | 181.19 |
| Purity | 99.0-101.0 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 385.2±32.0 °C at 760 mmHg |
| Melting Point | >300 °C (dec.) (lit.) |
| Appearance | powder |
| Water Solubility | 0.45 g/L (25 ºC) |
| Storage Condition | This product should be sealed and stored away from |
| Application | L-Tyrosine is a non-essential amino acid that inhibits citrate synthase activity in the posterior cortex. |
| EINECS | 200-460-4 |
| HTC | 29225000 |
| PubChem ID | 24900543 |
| MDL Number | MFCD00002606 |
| SMILES | N[C@@H](Cc1ccc(O)cc1)C(O)=O |
| InChI | 1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 |
| InChI Key | OUYCCCASQSFEME-QMMMGPOBSA-N |
| Beilstein/REAXYS | 392441 |
| NACRES Code | NA.26 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/16833_1_60_18_4.pdf |
| Bioactivity | L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. Related Catalog Research Areas >> Neurological Disease Natural Products >> Others Target Human Endogenous Metabolite In Vitro Results show that L-Tyrosine in vitro inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1, 1.0, 2.0 and 4.0 mM), hippocampus (1.0, 2.0 and 4.0 mM), striatum (4.0 mM) and liver (0.1, 1.0, 2.0 and 4.0 mM). When complex I activity is analyzed, inhibition is observed in hippocampus (4.0 mM). In addition to inhibition in the hippocampus, complex II also is inhibited in the posterior cortex (0.1, 1.0, 2.0 and 4.0 mM) and liver (1.0, 2.0 and 4.0 mM). For complex II-III, activity is not altered by L-Tyrosine, and complex IV activity has decreased in the posterior cortex (1.0, 2.0 and 4.0 mM) following treatment with L-Tyrosine[1]. In Vivo The acute administration of L-Tyrosine inhibits the activity of citrate synthase in the posterior cortex and liver; however, in the striatum, the activity is increased. The results also demonstrate that acute administration of L-Tyrosine inhibits malate dehydrogenase and complex II, II-III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum. Furthermore, energy metabolism in the hippocampus is not amended by an acute administration of L-Tyrosine[1]. Kinase Assay Posterior cortex, hippocampus, striatum and liver supernatants of 30-day-old rats are pre-incubated for 30 min at 30°C in the presence of L-Tyrosine (Tyr) at final concentrations ranging from 0.1, 1.0, 2.0 or 4.0 mM, and the activities of citrate synthase, malate dehydrogenase and respiratory chain complexes I, II, II-III and IV are evaluated[1]. Animal Admin The equivalent of 500 mg/kg body weight of free L-Tyrosine is intraperitoneally administered in 30-day-old rats. Controls receive in saline solution. About 1 h after injections, rats are killed by decapitation without anesthesia[1]. References [1]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 385.2±32.0 °C at 760 mmHg Melting Point >300 °C (dec.)(lit.) Molecular Formula C9H11NO3 Molecular Weight 181.189 Flash Point 186.7±25.1 °C Exact Mass 181.073898 PSA 83.55000 LogP 0.38 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.614 InChIKey OUYCCCASQSFEME-QMMMGPOBSA-N SMILES NC(Cc1ccc(O)cc1)C(=O)O Water Solubility 0.45 g/L (25 ºC) |
| Use of | L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. Properties Articles303 Name L-tyrosine Synonym More Synonyms L-Tyrosine Biological Activity Description L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. Related Catalog Research Areas >> Neurological Disease Natural Products >> Others Human Endogenous Metabolite In Vivo The acute administration of L-Tyrosine inhibits the activity of citrate synthase in the posterior cortex and liver; however, in the striatum, the activity is increased. The results also demonstrate that acute administration of L-Tyrosine inhibits malate dehydrogenase and complex II, II-III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum. Furthermore, energy metabolism in the hippocampus is not amended by an acute administration of L-Tyrosine[1]. References [1]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. Chemical & Physical Properties Molecular Formula C9H11NO3 Exact Mass 181.073898 PSA 83.55000 Index of Refraction 1.614 InChIKey OUYCCCASQSFEME-QMMMGPOBSA-N |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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