CAS Number57-57-8
SynonymsOxetan-2-one; 3-Hydroxypropanoic Acid b-Lactone; b-Propionolactone; β-propiolactone; 2-Oxetanone; Hydracrylic Acid b-Lactone; Hydracrylic acid β-lactone; propiolactone; beta-propiolactone; EINECS 200-340-1; β-Propionolactone; MFCD00005169
Molecular FormulaC8H12O2
Molecular Weight140.184
Purity95%
Density1.2±0.1 g/cm3
Boiling Point162.0±0.0 °C at 760 mmHg
Melting Point−33 °C(lit.)
AppearanceA colorless liquid with a slightly sweet, spicy odor
EINECS200-340-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57-57-8 |
| Catalog No. | 2A-9016749 |
| Chinese Name | 丙内酯 |
| Synonyms | Oxetan-2-one; 3-Hydroxypropanoic Acid b-Lactone; b-Propionolactone; β-propiolactone; 2-Oxetanone; Hydracrylic Acid b-Lactone; Hydracrylic acid β-lactone; propiolactone; beta-propiolactone; EINECS 200-340-1; β-Propionolactone; MFCD00005169 |
| Molecular Formula | C8H12O2 |
| Molecular Weight | 140.184 |
| Purity | 95 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 162.0±0.0 °C at 760 mmHg |
| Melting Point | −33 °C(lit.) |
| Appearance | A colorless liquid with a slightly sweet, spicy odor |
| Water Solubility | 37 g/100 mL |
| Storage Condition | Sealed and stored dry at 4°C. |
| Packaging | I |
| Application | Propiolactone (β-propiolactone; 2-Oxetanone) is a chemical inactivator of viruses that can cause infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 ( |
| EINECS | 200-340-1 |
| HTC | 2932209090 |
| UN(IATA) | UN 3382 |
| MDL Number | MFCD00005172 |
| SMILES | O=C1CCO1 |
| InChI | InChI=1S/C3H4O2/c4-3-1-2-5-3/h1-2H2 |
| InChI Key | VEZXCJBBBCKRPI-UHFFFAOYSA-N |
| Hazard Symbols | 6.1 |
| Risk Codes | R26;R36/38;R45 |
| Safety Description | S45;S53 |
| MSDS | msds/16749_1_57_57_8.pdf |
| Bioactivity | Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL)[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Target SARS-CoV-2[1] References [1]. Roberts A, et al. Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine. Viral Immunol. 2010 Oct;23(5):509-19 [2]. Kulkarni R, et al. Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA. J Virol Methods. 2021 Jan;287:113996. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 162.0±0.0 °C at 760 mmHg Melting Point −33 °C(lit.) Molecular Formula C3H4O2 Molecular Weight 72.063 Flash Point 35.0±16.1 °C Exact Mass 72.021126 PSA 26.30000 LogP -1.33 Vapour Pressure 2.2±0.3 mmHg at 25°C Index of Refraction 1.445 InChIKey VEZXCJBBBCKRPI-UHFFFAOYSA-N SMILES O=C1CCO1 Water Solubility 37 g/100 mL |
| Use of | Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL)[1][2]. Properties Articles38 Name β-propiolactone Synonym More Synonyms β-Propiolactone Biological Activity Description Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL)[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV SARS-CoV-2[1] References [1]. Roberts A, et al. Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine. Viral Immunol. 2010 Oct;23(5):509-19 [2]. Kulkarni R, et al. Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA. J Virol Methods. 2021 Jan;287:113996. Chemical & Physical Properties Molecular Formula C3H4O2 Exact Mass 72.021126 PSA 26.30000 LogP -1.33 Index of Refraction 1.445 InChIKey VEZXCJBBBCKRPI-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Chemical name |
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