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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 2-(2-Oxo-pyrrolidin-1-yl)acetamide
2-(2-Oxo-pyrrolidin-1-yl)acetamide structure, CAS 7491-74-9

2-(2-Oxo-pyrrolidin-1-yl)acetamide

CAS Number7491-74-9

Synonyms2-pyrrolidoneacetamide; Pyracetam; 2-(2-Oxo-1-pyrrolidinyl)acetamide; Gabacet; Normabrain; Nootropil; Nootrop; Ciclofalina; 2-Oxo-1-pyrrolidineacetamide; 2-(2-oxopyrrolidin-1-yl)acetamide; 5-21-06-00360 (Beilstein Handbook Reference); MFCD00079246; Piracetam; Nootropyl; Pyramem; EINECS 231-312-7

Molecular FormulaC6H10N2O2

Molecular Weight142.16

Purity98%

Density1.4±0.1 g/cm3

Boiling Point337.3±44.0 °C at 760 mmHg

Melting Point151-152ºC

Flash Point

Appearancepowder

EINECS231-312-7

MSDSChineseEnglish

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Cat. No.: 2A-9001349 Purity: 98%
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Quality Control of [ 7491-74-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number7491-74-9
Catalog No.2A-9001349
Chinese Name吡拉西坦
Synonyms2-pyrrolidoneacetamide; Pyracetam; 2-(2-Oxo-1-pyrrolidinyl)acetamide; Gabacet; Normabrain; Nootropil; Nootrop; Ciclofalina; 2-Oxo-1-pyrrolidineacetamide; 2-(2-oxopyrrolidin-1-yl)acetamide; 5-21-06-00360 (Beilstein Handbook Reference); MFCD00079246; Piracetam; Nootropyl; Pyramem; EINECS 231-312-7
Molecular FormulaC6H10N2O2
Molecular Weight142.16
Purity98
Density1.4±0.1 g/cm3
Boiling Point337.3±44.0 °C at 760 mmHg
Melting Point151-152ºC
Appearancepowder
Storage ConditionSealed in a cool, dry environment
ApplicationPiracetam is a cyclic derivative of GABA, which can act on a variety of cognitive disorders.
EINECS231-312-7
PubChem ID24278639
MDL NumberMFCD00079246
SMILESNC(=O)CN1CCCC1=O
InChI1S/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)
InChI KeyGMZVRMREEHBGGF-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/1349_1_7491_74_9.pdf
BioactivityPiracetam is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.Target: OthersPiracetam is able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. Preincubation of piracetam, at a piracetam/peptide ratio of 960, during 20 min before the addition of Abeta 29-42 prevents almost completely the mixture of the two fluorescent probes. Preincubation of piracetam with lipids prevents almost completely the release of calcein induced by the peptide in a dose-dependent fashion (piracetam/peptide ratios from 9.6 to 960) [1]. Piracetam (< 1.0 mM) preincubated with brain membranes enhances membrane fluidity in aged mice, rats and humans, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH). Piracetam (300 mg/kg once daily) significantly increases membrane fluidity in some brain regions of young and aged rats, but has no measurable effect on membrane fluidity in the young rats [2]. Piracetam (300 mg/kg daily for 6 weeks) improves active avoidance learning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in the aged rats. Piracetam (300 mg/kg daily for 6 weeks) also improves NMDA receptor density in the hippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to a lesser extent in the hippocampus of rats [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Mingeot-Leclercq, M.P., et al., Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment. Biochim Biophys Acta, 2003. 1609(1): p. 28-38. [2]. Muller, W.E., et al., Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain. Biochem Pharmacol, 1997. 53(2): p. 135-40. [3]. Scheuer, K., et al., Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain. Pharmacopsychiatry, 1999. 32 Suppl 1: p. 10-6. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 337.3±44.0 °C at 760 mmHg Melting Point 151-152ºC Molecular Formula C6H10N2O2 Molecular Weight 142.156 Flash Point 157.8±28.4 °C Exact Mass 142.074234 PSA 63.40000 LogP -1.39 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.603 InChIKey GMZVRMREEHBGGF-UHFFFAOYSA-N SMILES NC(=O)CN1CCCC1=O Storage condition Store at RT
Use ofProperties Articles81 Name 2-(2-oxopyrrolidin-1-yl)acetamide Synonym More Synonyms Piracetam Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Mingeot-Leclercq, M.P., et al., Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment. Biochim Biophys Acta, 2003. 1609(1): p. 28-38. [2]. Muller, W.E., et al., Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain. Biochem Pharmacol, 1997. 53(2): p. 135-40. [3]. Scheuer, K., et al., Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain. Pharmacopsychiatry, 1999. 32 Suppl 1: p. 10-6. Chemical & Physical Properties Molecular Formula C6H10N2O2 Exact Mass 142.074234 PSA 63.40000 LogP -1.39 Index of Refraction 1.603 InChIKey GMZVRMREEHBGGF-UHFFFAOYSA-N Storage condition Store at RT
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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