CAS Number74711-43-6
SynonymsPeon; (±)-10,11-Dihydro-a-methyl-10-oxodibenzo[b,f]thiepin-2-acetic Acid; 2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid; 10,11-Dihydro-α-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid; (±)-2-(10,11-Dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic Acid
Molecular FormulaC17H14O3S1
Molecular Weight298.36
Purity98%
Density1.3±0.1 g/cm3
Boiling Point500.5±50.0 °C at 760 mmHg
Melting Point129-131ºC
AppearanceOff-white to light yellow crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 74711-43-6 |
| Catalog No. | 2A-9012981 |
| Chinese Name | 扎托洛芬 |
| Synonyms | Peon; (±)-10,11-Dihydro-a-methyl-10-oxodibenzo[b,f]thiepin-2-acetic Acid; 2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid; 10,11-Dihydro-α-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid; (±)-2-(10,11-Dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic Acid |
| Molecular Formula | C17H14O3S1 |
| Molecular Weight | 298.36 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 500.5±50.0 °C at 760 mmHg |
| Melting Point | 129-131ºC |
| Appearance | Off-white to light yellow crystalline solid |
| Water Solubility | Water solubility: insoluble; easily soluble in: ac |
| Storage Condition | Refrigerator |
| Application | Zaltoprofen (CN100) is a COX inhibitor that can act on arthritis. |
| HTC | 2934999090 |
| MDL Number | MFCD00864323 |
| SMILES | CC(C(=O)O)c1ccc2c(c1)CC(=O)c1ccccc1S2 |
| InChI | InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20) |
| InChI Key | MUXFZBHBYYYLTH-UHFFFAOYSA-N |
| MSDS | msds/12981_1_74711_43_6.pdf |
| Bioactivity | Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. Target: COXZaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen had a moderate inhibitory effect compared with those of the above-mentioned NSAIDs. the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses is not explainable by the inhibition of cyclooxygenase (COX). Zaltoprofen did not bind to B(1) and B(2) receptors in a radio-ligand binding assay. In the cultured dorsal root ganglion cells of mature mice, zaltoprofen completely inhibited the bradykinin-induced increase of [Ca(2+)](i), which was inhibited by B(2) antagonist D-Arg-[Hyp(3), Thi(5,8), D-Phe(7)]-bradykinin, but not by B(1) antagonist. [1]. Related Catalog Research Areas >> Inflammation/Immunology Target COX-2:111 μM (IC50) COX-1:149 μM (IC50) References [1]. Hirate, K., et al., Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res, 2006. 54(4): p. 288-94. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 500.5±50.0 °C at 760 mmHg Melting Point 129-131ºC Molecular Formula C17H14O3S Molecular Weight 298.356 Flash Point 256.5±30.1 °C Exact Mass 298.066376 PSA 79.67000 LogP 3.68 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.656 InChIKey MUXFZBHBYYYLTH-UHFFFAOYSA-N SMILES CC(C(=O)O)c1ccc2c(c1)CC(=O)c1ccccc1S2 Storage condition Refrigerator |
| Use of | Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. Target: COXZaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen had a moderate inhibitory effect compared with those of the above-mentioned NSAIDs. the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses is not explainable by the inhibition of cyclooxygenase (COX). Zaltoprofen did not bind to B(1) and B(2) receptors in a radio-ligand binding assay. In the cultured dorsal root ganglion cells of mature mice, zaltoprofen completely inhibited the bradykinin-induced increase of [Ca(2+)](i), which was inhibited by B(2) antagonist D-Arg-[Hyp(3), Thi(5,8), D-Phe(7)]-bradykinin, but not by B(1) antagonist. [1]. Properties Name 10,11-Dihydro-Alpha-Methyl-10-Oxo-Dibenzo[b,f]Thiepin-2-Acetic Acid Synonym More Synonyms Zaltoprofen Biological Activity Description Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. Target: COXZaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen had a moderate inhibitory effect compared with those of the above-mentioned NSAIDs. the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses is not explainable by the inhibition of cyclooxygenase (COX). Zaltoprofen did not bind to B(1) and B(2) receptors in a radio-ligand binding assay. In the cultured dorsal root ganglion cells of mature mice, zaltoprofen completely inhibited the bradykinin-induced increase of [Ca(2+)](i), which was inhibited by B(2) antagonist D-Arg-[Hyp(3), Thi(5,8), D-Phe(7)]-bradykinin, but not by B(1) antagonist. [1]. Related Catalog Research Areas >> Inflammation/Immunology COX-2:111 μM (IC50) COX-1:149 μM (IC50) References [1]. Hirate, K., et al., Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res, 2006. 54(4): p. 288-94. Chemical & Physical Properties Molecular Formula C17H14O3S Exact Mass 298.066376 PSA 79.67000 Index of Refraction 1.656 InChIKey MUXFZBHBYYYLTH-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Zaltoprofen Modification Number: 4 |
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