CAS Number65-19-0
SynonymsUNII-NB2E1YP49F; Yohimbe HCl; (16α,17α)-17-Hydroxyyohimban-16-carboxylate de méthyle chlorhydrate; Yohimbine hydrochloride; Methyl (16α,17α)-17-hydroxyyohimban-16-carboxylate hydrochloride; Methyl (16α,17α)-17-hydroxyyohimban-16-carboxylate hydrochloride (1:1); MFCD00012674; Yohimbine HCl; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-, hydrochloride (1:1); Yohimban-16α-carboxylic acid, 17α-hydroxy-, methyl ester, monohydrochloride; Antagonil; Aphrodyne; EINECS 200-600-4; Yohimbine monohydrochloride; Yohimbine (Hydrochloride)
Molecular FormulaC21H27ClN2O3
Molecular Weight390.90
Purity98%
Boiling Point542.979ºC at 760 mmHg
Melting Point288-290 °C (dec.) (lit.)
AppearanceSlightly yellow needle-like
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 65-19-0 |
| Catalog No. | 2A-9012977 |
| Chinese Name | 盐酸育亨宾 |
| Synonyms | UNII-NB2E1YP49F; Yohimbe HCl; (16α,17α)-17-Hydroxyyohimban-16-carboxylate de méthyle chlorhydrate; Yohimbine hydrochloride; Methyl (16α,17α)-17-hydroxyyohimban-16-carboxylate hydrochloride; Methyl (16α,17α)-17-hydroxyyohimban-16-carboxylate hydrochloride (1:1); MFCD00012674; Yohimbine HCl; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-, hydrochloride (1:1); Yohimban-16α-carboxylic acid, 17α-hydroxy-, methyl ester, monohydrochloride; Antagonil; Aphrodyne; EINECS 200-600-4; Yohimbine monohydrochloride; Yohimbine (Hydrochloride) |
| Molecular Formula | C21H27ClN2O3 |
| Molecular Weight | 390.90 |
| Purity | 98 |
| Boiling Point | 542.979ºC at 760 mmHg |
| Melting Point | 288-290 °C (dec.) (lit.) |
| Appearance | Slightly yellow needle-like |
| Storage Condition | This product should be sealed, dry and protected f |
| Packaging | II |
| Application | Yohimbine hydrochloride is an alpha-2 adrenergic receptor inhibitor that blocks presynaptic or postsynaptic alpha-2 adrenergic receptors, causing the release of norepinephrine and dopamine. |
| HTC | 2933990090 |
| MDL Number | MFCD00012674 |
| SMILES | Cl.COC(=O)[C@H]1[C@@H](O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC12 |
| InChI | 1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1 |
| InChI Key | PIPZGJSEDRMUAW-VJDCAHTMSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/12977_1_65_19_0.pdf |
| Bioactivity | Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.IC50 value:Target:In vitro:In vivo: Yohimbine hydrochloride (0.2 mg/kg, i.p.) was administered to rats 1h before the stress session daily for 14 consecutive days and its effect was assessed. Results of this section revealed that, immersion of rats in cold water significantly decreased sexual arousal and motivation as indicated by increased latencies and intervals. Decreased copulatory activity was confirmed by decreased testosterone, luteinizing hormone (LH) and follicle-stimulating-hormone (FSH) levels as well as decreased cholesterol content in rat testes. Treatment with yohimbine significantly increased the sexual arousal and potency and corrected the effects induced by stress on the mating behavior of male rats [1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Natural Products >> Alkaloid Research Areas >> Others References [1]. Saad MA, et al. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats. [2]. Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4. [3]. Lahiri P, et al. Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome. Blood Cells Mol Dis. 2009 Jul-Aug;43(1):105-10. Chemical & Physical Properties Boiling Point 542.979ºC at 760 mmHg Melting Point 288-290 °C (dec.)(lit.) Molecular Formula C21H27ClN2O3 Molecular Weight 390.904 Flash Point 282.184ºC Exact Mass 390.171021 PSA 65.56000 LogP 3.38700 Index of Refraction 103 ° (C=1, H2O) InChIKey PIPZGJSEDRMUAW-VJDCAHTMSA-N SMILES COC(=O)C1C(O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC21.Cl Storage condition 2~8°C |
| Use of | Properties Articles35 Name Yohimbine hydrochloride Synonym More Synonyms Yohimbine hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Natural Products >> Alkaloid Research Areas >> Others References [1]. Saad MA, et al. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats. [2]. Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4. [3]. Lahiri P, et al. Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome. Blood Cells Mol Dis. 2009 Jul-Aug;43(1):105-10. Chemical & Physical Properties Exact Mass 390.171021 PSA 65.56000 LogP 3.38700 InChIKey PIPZGJSEDRMUAW-VJDCAHTMSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1544 International Maritime Transport Danger Regulations: 1544 International Air Transport Danger Regulations: 1544 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: ALKALOID SALTS, SOLID, N.O.S. (Yohimbine hydrochloride) IMDG Code: ALKALOID SALTS, SOLID, N.O.S. (Yohimbine hydrochloride) International air transport hazard regulations: Alkaloid salts, solid, n.o.s. (Yohimbine hydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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