CAS Number1218-35-5
SynonymsXylometazoline HCl; 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline Hydrochloride; Xylometazoline hydrochloride; 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, hydrochloride (1:1); 2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole hydrochloride (1:1); 2-[2,6-Dimethyl-4-(2-methyl-2-propanyl)benzyl]-4,5-dihydro-1H-imidazole hydrochloride (1:1); MFCD00238707; 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole,hydrochloride; EINECS 214-936-4; Xylometazoline (hydrochloride)
Molecular FormulaC16H25ClN2
Molecular Weight280.84
Purity99%
Boiling Point394.2ºC at 760 mmHg
Melting Point131-133ºC
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1218-35-5 |
| Catalog No. | 2A-9012976 |
| Chinese Name | 盐酸赛洛唑啉 |
| Synonyms | Xylometazoline HCl; 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline Hydrochloride; Xylometazoline hydrochloride; 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, hydrochloride (1:1); 2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole hydrochloride (1:1); 2-[2,6-Dimethyl-4-(2-methyl-2-propanyl)benzyl]-4,5-dihydro-1H-imidazole hydrochloride (1:1); MFCD00238707; 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole,hydrochloride; EINECS 214-936-4; Xylometazoline (hydrochloride) |
| Molecular Formula | C16H25ClN2 |
| Molecular Weight | 280.84 |
| Purity | 99 |
| Boiling Point | 394.2ºC at 760 mmHg |
| Melting Point | 131-133ºC |
| Appearance | White to off-white crystalline powder |
| Storage Condition | Room temperature, sealed, dry |
| Packaging | III |
| Application | Xylometazoline hydrochloride is an α-adrenergic receptor agonist and a nasal vasoconstrictor. |
| MDL Number | MFCD00238707 |
| SMILES | CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl |
| InChI | 1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H |
| InChI Key | YGWFCQYETHJKNX-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12976_1_1218_35_5.pdf |
| Bioactivity | Xylometazoline Hydrochloride is an α-adrenoceptor agonist commonly used as nasal decongestant.Target: α-AdrenoceptorXylometazoline is a nasal decongestant spray that constricts nasal blood vessels and increases nasal airflow, enabling patients with a blocked nose to breathe more easily. Xylometazoline is an effective and well-tolerated decongestant nasal spray that significantly relieved nasal congestion compared with placebo in the common cold and provided long-lasting relief with just 1 spray, helping patients to breathe more easily for a longer period of time [1]. Xylometazoline exhibited in radioligand competition studies higher affinities than the catecholamines adrenaline and noradrenaline at most α-adrenoceptor subtypes. Xylometazoline behaved at α(2B) -adrenoceptors as full agonists [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Eccles, R., et al., The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol, 2008. 22(5): p. 491-6. [2]. Haenisch, B., et al., Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol, 2010. 24(6): p. 729-39. Chemical & Physical Properties Boiling Point 394.2ºC at 760 mmHg Melting Point 131-133ºC Molecular Formula C16H25ClN2 Molecular Weight 280.836 Flash Point 192.2ºC Exact Mass 280.170624 PSA 24.39000 LogP 3.71150 Vapour Pressure 4.56E-06mmHg at 25°C InChIKey YGWFCQYETHJKNX-UHFFFAOYSA-N SMILES Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1.Cl |
| Use of | Xylometazoline Hydrochloride is an α-adrenoceptor agonist commonly used as nasal decongestant.Target: α-AdrenoceptorXylometazoline is a nasal decongestant spray that constricts nasal blood vessels and increases nasal airflow, enabling patients with a blocked nose to breathe more easily. Xylometazoline is an effective and well-tolerated decongestant nasal spray that significantly relieved nasal congestion compared with placebo in the common cold and provided long-lasting relief with just 1 spray, helping patients to breathe more easily for a longer period of time [1]. Xylometazoline exhibited in radioligand competition studies higher affinities than the catecholamines adrenaline and noradrenaline at most α-adrenoceptor subtypes. Xylometazoline behaved at α(2B) -adrenoceptors as full agonists [2]. Properties Articles32 Name Xylometazoline hydrochloride Synonym More Synonyms Xylometazoline hydrochloride Biological Activity Description Xylometazoline Hydrochloride is an α-adrenoceptor agonist commonly used as nasal decongestant.Target: α-AdrenoceptorXylometazoline is a nasal decongestant spray that constricts nasal blood vessels and increases nasal airflow, enabling patients with a blocked nose to breathe more easily. Xylometazoline is an effective and well-tolerated decongestant nasal spray that significantly relieved nasal congestion compared with placebo in the common cold and provided long-lasting relief with just 1 spray, helping patients to breathe more easily for a longer period of time [1]. Xylometazoline exhibited in radioligand competition studies higher affinities than the catecholamines adrenaline and noradrenaline at most α-adrenoceptor subtypes. Xylometazoline behaved at α(2B) -adrenoceptors as full agonists [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Eccles, R., et al., The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol, 2008. 22(5): p. 491-6. [2]. Haenisch, B., et al., Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol, 2010. 24(6): p. 729-39. Chemical & Physical Properties Exact Mass 280.170624 PSA 24.39000 LogP 3.71150 InChIKey YGWFCQYETHJKNX-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Xylometazoline hydrochloride Modification number: 5 Module 14. Shipping information Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: III |
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