CAS Number189188-57-6
Synonyms(2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide (2Z)-2-butenedioate; Zelnorm; Zelmac; MFCD04116201; Tegaserod Maleate; (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate; Tegaserod (maleate)
Molecular FormulaC20H27N5O5
Molecular Weight417.459
Purity98%
Boiling Point661.4ºC at 760 mmHg
Melting Point180-183ºC
Appearancewhite powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 189188-57-6 |
| Catalog No. | 2A-9012608 |
| Chinese Name | 马来酸替加色罗 |
| Synonyms | (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide (2Z)-2-butenedioate; Zelnorm; Zelmac; MFCD04116201; Tegaserod Maleate; (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate; Tegaserod (maleate) |
| Molecular Formula | C20H27N5O5 |
| Molecular Weight | 417.459 |
| Purity | 98 |
| Boiling Point | 661.4ºC at 760 mmHg |
| Melting Point | 180-183ºC |
| Appearance | white powder |
| Storage Condition | -20°C Freezer |
| Application | Tegaserod maleate is a 5-HT4 agonist. |
| HTC | 2933990090 |
| SMILES | CCCCCN=C(N)NN=Cc1c[nH]c2ccc(OC)cc12.O=C(O)C=CC(=O)O |
| InChI | InChI=1S/C16H23N5O.C4H4O4/c1-2-3-4-7-18-16(17)21-20-10-13-9-19-15-6-5-12(11-22)8-14(13)15;5-3(6)1-2-4(7)8/h5-6,8-10,20,22H,2-4,7,11H2,1H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b13-10+;2-1+ |
| InChI Key | CPDDZSSEAVLMRY-UHFFFAOYSA-N |
| MSDS | msds/12608_1_189188_57_6.pdf |
| Use of | Properties Name tegaserod maleate Synonym More Synonyms Tegaserod maleate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease References [1]. Bushman J, et al. Tegaserod mimics the neurostimulatory glycan polysialic acid and promotes nervous system repair. Neuropharmacology. 2014 Apr;79:456-66. [2]. Yan C, et al. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Braz J Med Biol Res. 2012 Oct;45(10):948-54. [3]. Painsipp E, et al. Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats. Br J Pharmacol. 2009 Nov;158(5):1210-26. Chemical & Physical Properties Molecular Formula C20H27N5O5 Exact Mass 417.201233 PSA 149.45000 LogP 3.10190 InChIKey CPDDZSSEAVLMRY-UHFFFAOYSA-N Safety Information RIDADR NONH for all modes of transport HS Code 2933990090 Synthetic Route Total: 1 Page Maleic acid CAS#:110-16-7 CAS#:145158-71-0 Tegaserod maleate CAS#:189188-57-6 Precursor & DownStream Precursor 2 CAS#:110-16-7 Maleic acid CAS#:145158-71-0 DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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