CAS Number17902-23-7
Synonymsriol; neberk; Tegafur; EXONAL; 5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; tetrahydrofuryl-5-fluorouracil; MFCD00012351; 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione; Carzonal; fulaid; lifril; EINECS 241-846-2; 5-fluoro-1-tetrahydrofuran-2-ylpyrimidine-2,4(1H,3H)-dione; FT-207; 5-Fluoro-1-(tetrahydro-2-furyl)uracil; 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil; FENTAL; Fluaid; lamar; N1-(2'-Furanidyl)-5-fluorouracil
Molecular FormulaC8H9FN2O3
Molecular Weight200.167
Purity98.00%
Density1.5±0.1 g/cm3
Melting Point171-173 °C(lit.)
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 17902-23-7 |
| Catalog No. | 2A-9012607 |
| Chinese Name | 替加氟 |
| Synonyms | riol; neberk; Tegafur; EXONAL; 5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; tetrahydrofuryl-5-fluorouracil; MFCD00012351; 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione; Carzonal; fulaid; lifril; EINECS 241-846-2; 5-fluoro-1-tetrahydrofuran-2-ylpyrimidine-2,4(1H,3H)-dione; FT-207; 5-Fluoro-1-(tetrahydro-2-furyl)uracil; 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil; FENTAL; Fluaid; lamar; N1-(2'-Furanidyl)-5-fluorouracil |
| Molecular Formula | C8H9FN2O3 |
| Molecular Weight | 200.167 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Melting Point | 171-173 °C(lit.) |
| Appearance | White crystalline powder |
| Storage Condition | 2-8°C |
| Application | Tegafur (Ftorafur) is the original drug of the anti-cancer agent 5-FU. |
| HTC | 2942000000 |
| SMILES | O=c1[nH]c(=O)n(C2CCCO2)cc1F |
| InChI Key | WFWLQNSHRPWKFK-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/12607_2_17902_23_7.pdf |
| Bioactivity | Tegafur (also known as Ftorafur) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil. IC50 value: Target: Nucleoside antimetabolite/analogTegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Cancer References [1]. Sotaro Sadahiro, Toshiyuki Suzuki, Akira Tanaka, et al. Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancer. Cancer Chemotherapy and Pharmacology. 2012, 70 (2): 285-291. [2]. José L. Ariasa, et al. Engineering of an antitumor (core/shell) magnetic nanoformulation based on the chemotherapy agent ftorafur. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2011,384(1-3): 157-163. [3]. Gabriel N. Hortobagyi, William Heim, Laura Hutchins, et al. A phase 2 study of a fixed combination of uracil and ftorafur (UFT) and leucovorin given orally in a 3-times-daily regimen to treat patients with recurrent metastatic breast cancer. Cancer. 2010, 116(6): 1440-1445. [4]. K. Fujita, H. Nakayama, W. Ichikawa, et al. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine). Drug Metab Dispos. 2009 Jul;37(7):1375-7. doi: 10.1124/dmd.109.027052. Epub 2009 Apr 23. [5]. Tegafur-uracil Chemical & Physical Properties Density 1.5±0.1 g/cm3 Melting Point 171-173 °C(lit.) Molecular Formula C8H9FN2O3 Molecular Weight 200.167 Exact Mass 200.059723 PSA 64.09000 LogP -0.77 Index of Refraction 1.557 InChIKey WFWLQNSHRPWKFK-UHFFFAOYSA-N SMILES O=c1[nH]c(=O)n(C2CCCO2)cc1F Storage condition 2-8°C |
| Use of | Tegafur (also known as Ftorafur) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil. IC50 value: Target: Nucleoside antimetabolite/analogTegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity. Properties Articles125 Name Tegafur Synonym More Synonyms Tegafur Biological Activity Description Tegafur (also known as Ftorafur) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil. IC50 value: Target: Nucleoside antimetabolite/analogTegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Cancer References [1]. Sotaro Sadahiro, Toshiyuki Suzuki, Akira Tanaka, et al. Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancer. Cancer Chemotherapy and Pharmacology. 2012, 70 (2): 285-291. [2]. José L. Ariasa, et al. Engineering of an antitumor (core/shell) magnetic nanoformulation based on the chemotherapy agent ftorafur. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2011,384(1-3): 157-163. [3]. Gabriel N. Hortobagyi, William Heim, Laura Hutchins, et al. A phase 2 study of a fixed combination of uracil and ftorafur (UFT) and leucovorin given orally in a 3-times-daily regimen to treat patients with recurrent metastatic breast cancer. Cancer. 2010, 116(6): 1440-1445. [5]. Tegafur-uracil Chemical & Physical Properties Molecular Formula C8H9FN2O3 Exact Mass 200.059723 PSA 64.09000 LogP -0.77 Index of Refraction 1.557 InChIKey WFWLQNSHRPWKFK-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (5-Fluoro-1-(tetrahydro-2-furyl)uracil) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (5-Fluoro-1-(tetrahydro-2-furyl)uracil) International air transport hazard regulations: Toxic solid, organic, n.o.s. (5-Fluoro-1-(tetrahydro-2-furyl)uracil) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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