CAS Number2447-57-6
Synonymssulphadoxin; 4-Amino-N-(5,6-dimethoxypyrimidin-4-yl)benzolsulfonamid; Sulfadimoxine; ro4-4393; Sulphadoxine; 4-amino-N-[5,6-bis(methyloxy)pyrimidin-4-yl]benzenesulfonamide; 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide,Sulfadoxin; SULFADOXIN; 4-Amino-N-(5,6-Dimethoxypyrimidin-4-Yl)Benzenesulfonamide; Sulfamethoxine; 4-amino-N-(4',5'-dimethoxy-6'-pyrimidinyl) benzene sulphonamide; SulphodoxiMe; Sulformetoxine; 4-amino-N-(5,6-diméthoxypyrimidin-4-yl)benzènesulfonamide; fanzil; wr4873; 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulphonamide; fanasil; 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide; Sulfadoxine; 6-(4,5-dimethoxy)pyrimidinesulfanilamide; 4-AMINO-N-(5,6-DIMETHOXY-4-PYRIMIDINYL)- BENZENESULFONAMID
Molecular FormulaC12H14N4O4S
Molecular Weight310.33
Purity98%
Density1.4±0.1 g/cm3
Boiling Point522.8±60.0 °C at 760 mmHg
Melting Point190-194ºC
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2447-57-6 |
| Catalog No. | 2A-9012524 |
| Chinese Name | 磺胺多辛 |
| Synonyms | sulphadoxin; 4-Amino-N-(5,6-dimethoxypyrimidin-4-yl)benzolsulfonamid; Sulfadimoxine; ro4-4393; Sulphadoxine; 4-amino-N-[5,6-bis(methyloxy)pyrimidin-4-yl]benzenesulfonamide; 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide,Sulfadoxin; SULFADOXIN; 4-Amino-N-(5,6-Dimethoxypyrimidin-4-Yl)Benzenesulfonamide; Sulfamethoxine; 4-amino-N-(4',5'-dimethoxy-6'-pyrimidinyl) benzene sulphonamide; SulphodoxiMe; Sulformetoxine; 4-amino-N-(5,6-diméthoxypyrimidin-4-yl)benzènesulfonamide; fanzil; wr4873; 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulphonamide; fanasil; 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide; Sulfadoxine; 6-(4,5-dimethoxy)pyrimidinesulfanilamide; 4-AMINO-N-(5,6-DIMETHOXY-4-PYRIMIDINYL)- BENZENESULFONAMID |
| Molecular Formula | C12H14N4O4S |
| Molecular Weight | 310.33 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 522.8±60.0 °C at 760 mmHg |
| Melting Point | 190-194ºC |
| Appearance | White crystalline powder |
| Water Solubility | Soluble in ethanol & ammonium hydroxide (9:1) at 2 |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Application | Sulfadoxine (Sulphadoxine) is a long-acting sulfonamide compound that is often combined with pyrimethamine to exert antimalarial effects. |
| HTC | 2935009090 |
| MDL Number | MFCD00792890 |
| SMILES | COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC |
| InChI | 1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16) |
| InChI Key | PJSFRIWCGOHTNF-UHFFFAOYSA-N |
| Beilstein/REAXYS | 625453 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12524_1_2447_57_6.pdf |
| Bioactivity | Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.Target: AntiparasiticSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html [2]. http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 522.8±60.0 °C at 760 mmHg Melting Point 190-194ºC Molecular Formula C12H14N4O4S Molecular Weight 310.329 Flash Point 270.0±32.9 °C Exact Mass 310.073578 PSA 124.81000 LogP 0.34 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.623 InChIKey PJSFRIWCGOHTNF-UHFFFAOYSA-N SMILES COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC Water Solubility Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml |
| Use of | Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.Target: AntiparasiticSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2]. Properties Articles75 Name sulfadoxine Synonym More Synonyms Sulfadoxine Biological Activity Description Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.Target: AntiparasiticSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html [2]. http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine Chemical & Physical Properties Molecular Formula C12H14N4O4S Exact Mass 310.073578 PSA 124.81000 Index of Refraction 1.623 InChIKey PJSFRIWCGOHTNF-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Purity: 96.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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