CAS Number69388-84-7
SynonymsSULBACTAM SODIUM SALT; sodium Penicillanate 1,1-Dioxide; SulbactaM SodiuM,USP; sulbacyam sodium; penicillanic acid 1,1-dioxide sodium salt; SODIUM SULBACTAM; EINECS 273-984-4; Sulbatam Sodium; SulbactaM SodiuM API; MFCD01750374
Molecular FormulaC8H10NNaO5S
Molecular Weight256.23
Purity≥98 (HPLC)%
Boiling Point567.7ºC at 760 mmHg
Melting Point121-123 °C(lit.)
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69388-84-7 |
| Catalog No. | 2A-9012520 |
| Chinese Name | 舒巴坦钠 |
| Synonyms | SULBACTAM SODIUM SALT; sodium Penicillanate 1,1-Dioxide; SulbactaM SodiuM,USP; sulbacyam sodium; penicillanic acid 1,1-dioxide sodium salt; SODIUM SULBACTAM; EINECS 273-984-4; Sulbatam Sodium; SulbactaM SodiuM API; MFCD01750374 |
| Molecular Formula | C8H10NNaO5S |
| Molecular Weight | 256.23 |
| Purity | ≥98 (HPLC) |
| Boiling Point | 567.7ºC at 760 mmHg |
| Melting Point | 121-123 °C(lit.) |
| Appearance | powder |
| Storage Condition | -20°C Freezer, Under Inert Atmosphere |
| Application | Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium has antimicrobial activity against the multidrug-resistant Acinetobacter-baumannii complex. |
| HTC | 2941109900 |
| MDL Number | MFCD01750374 |
| SMILES | O=C([C@@H]1N2[C@]([H])(S(=O)(C1(C)C)=O)CC2=O)O[Na] |
| InChI | InChI=1S/C8H11NO5S.Na/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14;/h5-6H,3H2,1-2H3,(H,11,12);/q;+1/p-1/t5-,6+;/m1./s1 |
| InChI Key | NKZMPZCWBSWAOX-IBTYICNHSA-M |
| NACRES Code | NA.21 |
| MSDS | msds/12520_1_69388_84_7.pdf |
| Use of | Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2]. Properties Articles28 Name Sulbactam sodium Synonym More Synonyms Sulbactam sodium Biological Activity Description Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vitro Ampicillin-Sulbactam has a wide range of antibacterial activity that includes Gram-positive and Gram-negative aerobic and anaerobic bacteria[3]. References [1]. Noguchi JK, et al. Sulbactam: a beta-lactamase inhibitor. Clin Pharm. 1988;7(1):37-51. [2]. Lin HS, et al. Sulbactam treatment for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Infect Dis (Lond). 2015;47(6):370-378. [3]. Betrosian AP, et al. Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. Expert Opin Drug Metab Toxicol. 2009;5(9):1099-1112. Chemical & Physical Properties Molecular Formula C8H10NNaO5S Exact Mass 255.017731 PSA 102.96000 InChIKey NKZMPZCWBSWAOX-IBTYICNHSA-M Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S-cis)- CAS REGISTRY NUMBER : 69388-84-7 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C8-H10-N-O2-S.Na MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,1106,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Liver - changes in liver weight REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Liver - changes in liver weight REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 17-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),108,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 17-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),108,1984 Safety Information Hazard Codes Xn: Harmful; WGK Germany 3 HS Code 2941109900 Synthetic Route Total: 1 Page CAS#:68373-14-8 Sulbactam sodium CAS#:69388-84-7 Diethyl phosphite CAS#:762-04-9 (3S)-6,6-DIBROM... CAS#:76646-91-8 Sulbactam sodium CAS#:69388-84-7 Literature: Leo Pharmaceutical Products Ltd. A/S Patent: US4816580 A1, 1989 ; Precursor & DownStream Precursor 3 CAS#:68373-14-8 CAS#:762-04-9 Diethyl phosphite CAS#:76646-91-8 (3S)-6,6-DIBROM... DownStream 4 CAS#:69388-79-0 Sulbactam pivoxil CAS#:68373-14-8 CAS#:926-61-4 3-oxopropanoic acid CAS#:98462-04-5 Valine, 3-sulfino |
| Transport Info | Product Name: Sulbactam Sodium |
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