CAS Number68373-14-8
Synonymspenicillanic acid S,S-dioxide; 6,6-dihydropenicillanic acid S,S-dioxide; EINECS 269-878-2; 4,4-dioxopenicillanic acid; (2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-Dioxide; penicillanic Acid 1,1-Dioxide; DSSTox_CID_3605; UNII-S4TF6I2330; Sulbactam free acid; (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ<sup>6</sup>-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Penicillanic Acid Sulfone; Unacim; (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide; Sulbactamum; Sulbactam; acide (2S,5R)-3,3-diméthyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylique-4,4-dioxyde
Molecular FormulaC8H11NO5S
Molecular Weight256.23
Purity≥98 (HPLC)%
Density1.6±0.1 g/cm3
Boiling Point567.7±50.0 °C at 760 mmHg
Melting Point146-151ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68373-14-8 |
| Catalog No. | 2A-9012518 |
| Chinese Name | 舒巴坦酸 |
| Synonyms | penicillanic acid S,S-dioxide; 6,6-dihydropenicillanic acid S,S-dioxide; EINECS 269-878-2; 4,4-dioxopenicillanic acid; (2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-Dioxide; penicillanic Acid 1,1-Dioxide; DSSTox_CID_3605; UNII-S4TF6I2330; Sulbactam free acid; (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ<sup>6</sup>-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Penicillanic Acid Sulfone; Unacim; (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide; Sulbactamum; Sulbactam; acide (2S,5R)-3,3-diméthyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylique-4,4-dioxyde |
| Molecular Formula | C8H11NO5S |
| Molecular Weight | 256.23 |
| Purity | ≥98 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 567.7±50.0 °C at 760 mmHg |
| Melting Point | 146-151ºC |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | Sulbactam (Betamaze) is an irreversible beta-lactamase inhibitor. |
| HTC | 2941109900 |
| MDL Number | MFCD01750374 |
| SMILES | O=C([C@@H]1N2[C@]([H])(S(=O)(C1(C)C)=O)CC2=O)O[Na] |
| InChI | InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 |
| InChI Key | FKENQMMABCRJMK-RITPCOANSA-N |
| NACRES Code | NA.21 |
| Hazard Symbols | Transport |
| MSDS | msds/12518_1_68373_14_8.pdf |
| Bioactivity | Sulbactam(Betamaze) is an irreversible β-lactamase inhibitor.Target: β-lactamase; AntibacterialSulbactam is a mechanism-based inhibitor of beta-lactamase enzymes used in clinical practice. sulbactam was the antimicrobial agent responsible for the killing of these organisms [1]. sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Urban, C., et al., Effect of sulbactam on infections caused by imipenem-resistant Acinetobacter calcoaceticus biotype anitratus. J Infect Dis, 1993. 167(2): p. 448-51. [2]. Corbella, X., et al., Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii. J Antimicrob Chemother, 1998. 42(6): p. 793-802. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 567.7±50.0 °C at 760 mmHg Melting Point 146-151ºC Molecular Formula C8H11NO5S Molecular Weight 233.242 Flash Point 297.1±30.1 °C Exact Mass 233.035797 PSA 100.13000 LogP -1.39 Vapour Pressure 0.0±3.4 mmHg at 25°C Index of Refraction 1.605 InChIKey FKENQMMABCRJMK-RITPCOANSA-N SMILES CC1(C)C(C(=O)O)N2C(=O)CC2S1(=O)=O Storage condition -20°C |
| Use of | Sulbactam(Betamaze) is an irreversible β-lactamase inhibitor.Target: β-lactamase; AntibacterialSulbactam is a mechanism-based inhibitor of beta-lactamase enzymes used in clinical practice. sulbactam was the antimicrobial agent responsible for the killing of these organisms [1]. sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem [2]. Properties Articles75 Name sulbactam Synonym More Synonyms Sulbactam Biological Activity Description Sulbactam(Betamaze) is an irreversible β-lactamase inhibitor.Target: β-lactamase; AntibacterialSulbactam is a mechanism-based inhibitor of beta-lactamase enzymes used in clinical practice. sulbactam was the antimicrobial agent responsible for the killing of these organisms [1]. sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Urban, C., et al., Effect of sulbactam on infections caused by imipenem-resistant Acinetobacter calcoaceticus biotype anitratus. J Infect Dis, 1993. 167(2): p. 448-51. [2]. Corbella, X., et al., Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii. J Antimicrob Chemother, 1998. 42(6): p. 793-802. Chemical & Physical Properties Molecular Formula C8H11NO5S Exact Mass 233.035797 PSA 100.13000 LogP -1.39 Index of Refraction 1.605 InChIKey FKENQMMABCRJMK-RITPCOANSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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