CAS Number112665-43-7
Synonyms7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid; Bronica; MFCD00875701; 7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)heptanoic acid
Molecular FormulaC22H26O4
Molecular Weight354.44
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point522.3±49.0 °C at 760 mmHg
Melting Point118-120°C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 112665-43-7 |
| Catalog No. | 2A-9012424 |
| Chinese Name | 塞曲司特 |
| Synonyms | 7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid; Bronica; MFCD00875701; 7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)heptanoic acid |
| Molecular Formula | C22H26O4 |
| Molecular Weight | 354.44 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 522.3±49.0 °C at 760 mmHg |
| Melting Point | 118-120°C |
| Appearance | powder |
| Storage Condition | Store at +4°C |
| Packaging | III |
| Application | Seratrodast (AA 2414) is a thromboxane A2 receptor (TP) antagonist. |
| HTC | 29309070 |
| PubChem ID | 329825828 |
| MDL Number | MFCD00875701 |
| SMILES | O=C(C(C)=C1C)C(C)=C(C(CCCCCC(O)=O)C2=CC=CC=C2)C1=O |
| InChI | 1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24) |
| InChI Key | ZBVKEHDGYSLCCC-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| Hazard Symbols | 6.1 |
| MSDS | msds/12424_1_112665_43_7.pdf |
| Bioactivity | Seratrodast(AA 2414) is a potent and selective thromboxane A2 receptor (TP) antagonist.Target: Thromboxane A2 ReceptorSeratrodast, also known as AA-2414, is a potent and selective antagonist of the TXA2R (thromboxane A2 receptor). AA-2414 reduced the induction of pulmonary inflation caused by LTD4 aerosol inhalation. AA-2414 competitively inhibited the contractile response to U-46619 in guinea pig tracheal and parenchymal strips and dog saphenous vein strips with pA2 values of 7.69, 8.29 and 6.79, respectively. AA-2414, a quinone derivative, is a novel, potent and orally active antagonist of a variety of spasmogenic prostanoids [1]. AA-2414 inhibited peroxide-induced vasoconstriction in the human placenta, as well as peroxide- induced increases in the placental secretion rates of lipid peroxides and thromboxane, but only partially inhibited peroxide-induced increases in the placental secretion rate of prostacyclin [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology References [1]. Ashida, Y., et al., A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins, 1989. 38(1): p. 91-112. [2]. Walsh, S.W., Y. Wang, and A. Killian, AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. J Pharmacol Exp Ther, 1999. 290(1): p. 220-6. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 522.3±49.0 °C at 760 mmHg Melting Point 118-120°C Molecular Formula C22H26O4 Molecular Weight 354.439 Flash Point 283.8±26.3 °C Exact Mass 354.183105 PSA 71.44000 LogP 5.25 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.555 InChIKey ZBVKEHDGYSLCCC-UHFFFAOYSA-N SMILES CC1=C(C)C(=O)C(C(CCCCCC(=O)O)c2ccccc2)=C(C)C1=O Storage condition Store at +4°C |
| Use of | Properties Name Seratrodast Synonym More Synonyms Seratrodast Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology References [1]. Ashida, Y., et al., A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins, 1989. 38(1): p. 91-112. [2]. Walsh, S.W., Y. Wang, and A. Killian, AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. J Pharmacol Exp Ther, 1999. 290(1): p. 220-6. Chemical & Physical Properties Molecular Formula C22H26O4 Exact Mass 354.183105 PSA 71.44000 Index of Refraction 1.555 InChIKey ZBVKEHDGYSLCCC-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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