CAS Number145202-66-0
SynonymsRizatriptan benzoate salt; N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate; N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine benzoate; Rizatriptan benzoate; 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, benzoate (1:1); N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine benzoate (1:1); Maxalt; MK-462 (N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt; Rizatrimptan benzoate; MFCD00866224; Benzolcarbonsäure--N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamin(1:1); N,N-diméthyl-2-[5-(1H-1,2,4-triazol-1-ylméthyl)-1H-indol-3-yl]éthanamine benzoate; Rizatriptan; N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine Benzoate
Molecular FormulaC22H25N5O2
Molecular Weight391.47
Purity≥98 (HPLC)%
Density1.21g/cm3
Boiling Point504.8ºC at 760mmHg
Melting Point178-180°C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 145202-66-0 |
| Catalog No. | 2A-9012325 |
| Chinese Name | 苯甲酸利扎曲坦 |
| Synonyms | Rizatriptan benzoate salt; N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate; N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine benzoate; Rizatriptan benzoate; 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, benzoate (1:1); N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine benzoate (1:1); Maxalt; MK-462 (N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt; Rizatrimptan benzoate; MFCD00866224; Benzolcarbonsäure--N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamin(1:1); N,N-diméthyl-2-[5-(1H-1,2,4-triazol-1-ylméthyl)-1H-indol-3-yl]éthanamine benzoate; Rizatriptan; N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine Benzoate |
| Molecular Formula | C22H25N5O2 |
| Molecular Weight | 391.47 |
| Purity | ≥98 (HPLC) |
| Density | 1.21g/cm3 |
| Boiling Point | 504.8ºC at 760mmHg |
| Melting Point | 178-180°C |
| Appearance | powder |
| Water Solubility | Water solubility: soluble; water solubility: 53 g/ |
| Storage Condition | -20°C Freezer |
| Application | Rizatriptan benzoate (Maxalt) is a 5-HT1 agonist. |
| HTC | 2933990090 |
| UN(IATA) | NA |
| PubChem ID | 329825257 |
| MDL Number | MFCD00866224 |
| SMILES | OC(=O)c1ccccc1.CN(C)CCc2c[nH]c3ccc(Cn4cncn4)cc23 |
| InChI | 1S/C15H19N5.C7H6O2/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;8-7(9)6-4-2-1-3-5-6/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3;1-5H,(H,8,9) |
| InChI Key | JPRXYLQNJJVCMZ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/12325_1_145202_66_0.pdf |
| Bioactivity | Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.Target: 5-HT1 agonist Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. It is believed to work by narrowing the blood vessels around the brain. Rizatriptan also reduces the substances in the body, which can also reduce headache pain, nausea, sensitivity to light and sound and other migraine symptoms.Rizatriptan was rapidly absorbed with a median tmax of 1.3 h (range 1-3 h) vs a tmax for sumatriptan of 2.5 h (range 1-4 h, P < 0.001). Administration of either rizatriptan or sumatriptan produced maximal mean elevations of 5-10 mmHg in systolic and diastolic blood pressures without effect on heart rate; the changes occurred sooner following rizatriptan, consistent with more rapid absorption. Both rizatriptan and sumatriptan provoked mild increases in serum growth hormone without any effect on serum prolactin concentrations. The most commonly reported symptom following rizatriptan was drowsiness. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor References [1]. Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43(1):49-54. Chemical & Physical Properties Density 1.21g/cm3 Boiling Point 504.8ºC at 760mmHg Melting Point 178-180°C Molecular Formula C22H25N5O2 Molecular Weight 391.466 Flash Point 259.1ºC Exact Mass 391.200836 PSA 87.04000 LogP 3.29660 Vapour Pressure 2.58E-10mmHg at 25°C Index of Refraction 1.645 InChIKey JPRXYLQNJJVCMZ-UHFFFAOYSA-N SMILES CN(C)CCc1c[nH]c2ccc(Cn3cncn3)cc12.O=C(O)c1ccccc1 Storage condition -20°C Freezer |
| Use of | Properties Articles25 Name Rizatriptan Benzoate Synonym More Synonyms Rizatriptan benzoate Biological Activity Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor References [1]. Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43(1):49-54. Chemical & Physical Properties Molecular Formula C22H25N5O2 Exact Mass 391.200836 PSA 87.04000 LogP 3.29660 Index of Refraction 1.645 InChIKey JPRXYLQNJJVCMZ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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