CAS Number518-28-5
SynonymsEINECS 208-250-4; Podofilox; Podophyllotoxin; Wartec; Condylox; Condyline; Warticon; MFCD00075290; Podophyllinic acid lactone
Molecular FormulaC22H22O8
Molecular Weight414.41
Purity99%
Density1.4±0.1 g/cm3
Boiling Point597.9±50.0 °C at 760 mmHg
Melting Point183-184 °C(lit.)
AppearanceLight yellow-beige powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 518-28-5 |
| Catalog No. | 2A-9012066 |
| Chinese Name | 鬼臼毒素 |
| Synonyms | EINECS 208-250-4; Podofilox; Podophyllotoxin; Wartec; Condylox; Condyline; Warticon; MFCD00075290; Podophyllinic acid lactone |
| Molecular Formula | C22H22O8 |
| Molecular Weight | 414.41 |
| Purity | 99 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 597.9±50.0 °C at 760 mmHg |
| Melting Point | 183-184 °C(lit.) |
| Appearance | Light yellow-beige powder |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Packaging | II |
| Application | Podophyllotoxin is an inhibitor of microtubule assembly and DNA topoisomerase II. |
| HTC | 2942000000 |
| MDL Number | C22H22O8 |
| SMILES | COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 |
| InChI | InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1 |
| InChI Key | InChIKey=YJGVMLPVUAXIQN-XVVDYKMHSA-N |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/12066_1_518_28_5.pdf |
| Bioactivity | Podophyllotoxin is a potent inhibitor of microtubule assembly and DNA topoisomerase II.IC50 Value:Target: Topoisomerase II; Microtubule/TubulinPodophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Natural Products >> Phenylpropanoids Research Areas >> Cancer References [1]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75. [2]. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31. [3]. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263. [4]. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8. [5]. Podophyllotoxin Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 597.9±50.0 °C at 760 mmHg Melting Point 183-184 °C(lit.) Molecular Formula C22H22O8 Molecular Weight 414.405 Flash Point 210.2±23.6 °C Exact Mass 414.131470 PSA 92.68000 LogP 1.60 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.606 |
| Use of | Podophyllotoxin is a potent inhibitor of microtubule assembly and DNA topoisomerase II.IC50 Value:Target: Topoisomerase II; Microtubule/TubulinPodophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use. Properties Articles172 Name podophyllotoxin Synonym More Synonyms Podophyllotoxin Biological Activity Description Podophyllotoxin is a potent inhibitor of microtubule assembly and DNA topoisomerase II.IC50 Value:Target: Topoisomerase II; Microtubule/TubulinPodophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Natural Products >> Phenylpropanoids Research Areas >> Cancer References [1]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75. [2]. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31. [3]. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263. [4]. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8. [5]. Podophyllotoxin Chemical & Physical Properties Molecular Formula C22H22O8 Exact Mass 414.131470 PSA 92.68000 Index of Refraction 1.606 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3462 International Maritime Transport Danger Regulations: 3462 International Air Transport Danger Regulations: 3462 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXINS EXTRAC TED FROM LIVING SOURCES, SOLID, N.O.S. (1,3,3a,4,9,9a- Hexahydro-9-hydroxy-6,7-(methylenedioxy)-4-(3',4',5'- trimethoxyphenyl)benz[f]isobenzofuran-3-one) IMDG Code: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (1,3,3a,4,9,9a- Hexahydro-9-hydroxy-6,7-(methylenedioxy)-4-(3',4',5'- trimethoxyphenyl)benz[f]isobenzofuran-3-one) International air transport hazard regulations: Toxins, extracted from living sources, solid, n.o.s. (1,3,3a,4,9,9a-Hexahydro-9-hydroxy-6,7- (methylenedioxy)-4-(3',4',5'-trimethoxyphenyl)benz[f]isobenzofuran-3-one) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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