CAS Number161735-79-1
Synonymsacide méthanesulfonique - (1R)-N-prop-2-yn-1-yl-2,3-dihydro-1H-indén-1-amine (1:1); Methansulfonsäure--(1R)-N-prop-2-in-1-yl-2,3-dihydro-1H-inden-1-amin(1:1); methanesulfonic acid,(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine; (1R)-N-(Prop-2-yn-1-yl)indan-1-amine methanesulfonate (1:1); (1R)-N-(2-Propyn-1-yl)-1-indanamine methanesulfonate (1:1); (1R)-N-prop-2-yn-1-yl-2,3-dihydro-1H-inden-1-amine methanesulfonate; Rasagiline mesylate; (R)-N-(Prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate; (1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate (1:1); 1H-Inden-1-amine, 2,3-dihydro-N-2-propyn-1-yl-, (1R)-, methanesulfonate (1:1); 1H-inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R)-, methanesulfonate (1:1); Rasagiline (mesylate)
Molecular FormulaC13H17NO3S
Molecular Weight267.35
Purity98%
Density1.05 g/cm3
Boiling Point305.5ºC at 760 mmHg
Melting Point155-158°C
Appearancewhite powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 161735-79-1 |
| Catalog No. | 2A-9012271 |
| Chinese Name | 甲磺酸雷沙吉兰 |
| Synonyms | acide méthanesulfonique - (1R)-N-prop-2-yn-1-yl-2,3-dihydro-1H-indén-1-amine (1:1); Methansulfonsäure--(1R)-N-prop-2-in-1-yl-2,3-dihydro-1H-inden-1-amin(1:1); methanesulfonic acid,(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine; (1R)-N-(Prop-2-yn-1-yl)indan-1-amine methanesulfonate (1:1); (1R)-N-(2-Propyn-1-yl)-1-indanamine methanesulfonate (1:1); (1R)-N-prop-2-yn-1-yl-2,3-dihydro-1H-inden-1-amine methanesulfonate; Rasagiline mesylate; (R)-N-(Prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate; (1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate (1:1); 1H-Inden-1-amine, 2,3-dihydro-N-2-propyn-1-yl-, (1R)-, methanesulfonate (1:1); 1H-inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R)-, methanesulfonate (1:1); Rasagiline (mesylate) |
| Molecular Formula | C13H17NO3S |
| Molecular Weight | 267.35 |
| Purity | 98 |
| Density | 1.05 g/cm3 |
| Boiling Point | 305.5ºC at 760 mmHg |
| Melting Point | 155-158°C |
| Appearance | white powder |
| Storage Condition | -20°C Freezer |
| Application | Rasagiline mesylate is an MAO-B inhibitor that can act on primary Parkinson's disease. |
| HTC | 2921499090 |
| MDL Number | C13H17NO3S |
| SMILES | C#CCNC1CCc2ccccc21.CS(=O)(=O)O |
| InChI | InChI=1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1 |
| InChI Key | JDBJJCWRXSVHOQ-UTONKHPSSA-N |
| MSDS | msds/12271_1_161735_79_1.pdf |
| Bioactivity | Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. Target: Monoamine Oxidase (MAO)-BRasagiline (N-propargyl-1-(R)-aminoindan) is a novel, highly potent irreversible monoamine oxidase (MAO)-B inhibitor, anti-Parkinsonian drug. Rasagiline is effective as monotherapy or adjunct to L-Dopa for patients with early and late Parkinson's disease (PD) [1]. Rasagiline inhibits MAO-B more potently than selegiline and has the advantage of once-daily dosing. In several large, randomized, placebo-controlled trials, rasagiline has demonstrated efficacy as monotherapy in early PD and as adjunctive therapy in advanced PD. In addition, rasagiline has been shown to have neuroprotective effects in in vitro and in vivo studies. The recently completed delayed-start ADAGIO (Attenuation of Disease Progression with Azilect Given Once-daily) trial suggests a potential disease-modifying effect for rasagiline 1 mg/day, though the clinical import of this finding has yet to be established [2]. Rasagiline has been found to be well tolerated and effective in the treatment of early PD and as adjunctive treatment in motor fluctuations. Whether rasagiline is associated with clinically significant neuroprotection (ie, disease modification) in PD is the subject of ongoing clinical trials [3]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease References [1]. Weinreb, O., et al., Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity. Prog Neurobiol, 2010. 92(3): p. 330-44. [2]. Leegwater-Kim, J. and E. Bortan, The role of rasagiline in the treatment of Parkinson's disease. Clin Interv Aging, 2010. 5: p. 149-56. [3]. Chen, J.J., D.M. Swope, and K. Dashtipour, Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease. Clin Ther, 2007. 29(9): p. 1825-49. [4]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153. Chemical & Physical Properties Density 1.05 g/cm3 Boiling Point 305.5ºC at 760 mmHg Melting Point 155-158°C Molecular Formula C13H17NO3S Molecular Weight 267.344 Flash Point 146.8ºC Exact Mass 267.092926 PSA 74.78000 LogP 2.87240 Vapour Pressure 0.000816mmHg at 25°C InChIKey JDBJJCWRXSVHOQ-UTONKHPSSA-N SMILES C#CCNC1CCc2ccccc21.CS(=O)(=O)O Storage condition -20°C Freezer |
| Use of | Properties Name Rasagiline Mesylate Synonym More Synonyms Rasagiline mesylate Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease References [1]. Weinreb, O., et al., Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity. Prog Neurobiol, 2010. 92(3): p. 330-44. [2]. Leegwater-Kim, J. and E. Bortan, The role of rasagiline in the treatment of Parkinson's disease. Clin Interv Aging, 2010. 5: p. 149-56. [3]. Chen, J.J., D.M. Swope, and K. Dashtipour, Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease. Clin Ther, 2007. 29(9): p. 1825-49. [4]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153. Chemical & Physical Properties Molecular Formula C13H17NO3S Exact Mass 267.092926 PSA 74.78000 LogP 2.87240 InChIKey JDBJJCWRXSVHOQ-UTONKHPSSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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