CAS Number95635-55-5
Synonyms(±)-1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[N-(2,6-dimethylphenyl)carbamoylmethyl]piperazine; (±)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide; RAN D; Renexa; 1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]; N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamid; CVT 303; N-(2,6-diméthylphényl)-2-{4-[2-hydroxy-3-(2-méthoxyphénoxy)propyl]pipérazin-1-yl}acétamide; (±)-4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2',6'-xylidide; 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethy]piperazine; N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl}acetamide; Ranolazine; N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(
Molecular FormulaC24H33N3O4
Molecular Weight427.54
Purity99%
Density1.2±0.1 g/cm3
Boiling Point624.1±55.0 °C at 760 mmHg
Melting Point119-1200C
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 95635-55-5 |
| Catalog No. | 2A-9012268 |
| Chinese Name | 雷诺嗪 |
| Synonyms | (±)-1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[N-(2,6-dimethylphenyl)carbamoylmethyl]piperazine; (±)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide; RAN D; Renexa; 1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]; N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamid; CVT 303; N-(2,6-diméthylphényl)-2-{4-[2-hydroxy-3-(2-méthoxyphénoxy)propyl]pipérazin-1-yl}acétamide; (±)-4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2',6'-xylidide; 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethy]piperazine; N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl}acetamide; Ranolazine; N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-( |
| Molecular Formula | C24H33N3O4 |
| Molecular Weight | 427.54 |
| Purity | 99 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 624.1±55.0 °C at 760 mmHg |
| Melting Point | 119-1200C |
| Appearance | white solid |
| Storage Condition | -20°C Freezer |
| Application | Ranolazine has antiarrhythmic activity. |
| HTC | 2933990090 |
| MDL Number | MFCD00864690 |
| SMILES | N2(CCN(CC2)CC(=O)Nc3c(cccc3C)C)CC(O)COc1c(cccc1)OC |
| InChI | 1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29) |
| InChI Key | XKLMZUWKNUAPSZ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12268_1_95635_55_5.pdf |
| Use of | Ranolazine is an antianginal medication.Target: Sodium ChannelRanolazine is believed to have its effects via altering the transcellular late sodium current. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the intracellular sodium level [1]. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia in rats [2]. The effects of ranolazine on the NaV 1.7 and NaV 1.8 sodium channels also make it potentially useful in the treatment of neuropathic pain. Ranolazine produced dose-dependant analgesia on mechanical allodynia induced by CFA injection, but had no effect on thermal hyperalgesia [3, 4]. Properties Name Ranolazine Synonym More Synonyms Ranolazine Biological Activity Description Ranolazine is an antianginal medication.Target: Sodium ChannelRanolazine is believed to have its effects via altering the transcellular late sodium current. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the intracellular sodium level [1]. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia in rats [2]. The effects of ranolazine on the NaV 1.7 and NaV 1.8 sodium channels also make it potentially useful in the treatment of neuropathic pain. Ranolazine produced dose-dependant analgesia on mechanical allodynia induced by CFA injection, but had no effect on thermal hyperalgesia [3, 4]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Natural Products >> Others References [1]. Hale, S.L. and R.A. Kloner, Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther, 2006. 11(4): p. 249-55. [2]. Fraser, H., et al., Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol, 2006. 41(6): p. 1031-8. [3]. Gould, H.J., 3rd, et al., Ranolazine attenuates behavioral signs of neuropathic pain. Behav Pharmacol, 2009. 20(8): p. 755-8. [4]. Casey, G.P., et al., Ranolazine attenuation of CFA-induced mechanical hyperalgesia. Pain Med, 2010. 11(1): p. 119-26. Chemical & Physical Properties Molecular Formula C24H33N3O4 Exact Mass 427.247101 PSA 74.27000 Index of Refraction 1.586 InChIKey XKLMZUWKNUAPSZ-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 1-(2-methoxyphe... 162712-35-8 2-Chloro-N-(2,6... Ranolazine 95635-55-5 1-chloro-3-(2-m... 25772-81-0 N-(2,6-Dimethyl... Ranolazine 95635-55-5 Guaiacol glycid... N-(2,6-Dimethyl... Ranolazine 95635-55-5 Literature: Pathare, Sagar P.; Akamanchi, Krishnacharya G. Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6455 - 6459 Precursor & DownStream Precursor 7 CAS#:162712-35-8 1-(2-methoxyphe... CAS#:1131-01-7 2-Chloro-N-(2,6... CAS#:5294-61-1 N-(2,6-Dimethyl... CAS#:2210-74-4 Guaiacol glycid... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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