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Ranolazine dihydrochloride structure, CAS 95635-56-6

Ranolazine dihydrochloride

CAS Number95635-56-6

SynonymsRanolazine dihydrochloride; RANOLAZINE HCL; MFCD03788770; RANOLAZINE DI HCL; Ranolazine (dihydrochloride); Ranolazine DiHCI; Ranolazine and salt; Ranolazine Dihydrocloride; Ranolazine 2HCl; Ranolazine dihydroch

Molecular FormulaC24H35Cl2N3O4

Molecular Weight500.46

Purity≥98 (HPLC)%

Density

Boiling Point624.1ºC at 760 mmHg

Melting Point222-229.5 °C (lit.)

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9012269 Purity: ≥98 (HPLC)%
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Quality Control of [ 95635-56-6 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number95635-56-6
Catalog No.2A-9012269
Chinese NameN-(2,6-二甲基苯基)-2-(4-(2-羟基-3-(2-甲氧基苯氧基)-丙基)哌嗪-1-基)乙酰胺 二盐酸盐
SynonymsRanolazine dihydrochloride; RANOLAZINE HCL; MFCD03788770; RANOLAZINE DI HCL; Ranolazine (dihydrochloride); Ranolazine DiHCI; Ranolazine and salt; Ranolazine Dihydrocloride; Ranolazine 2HCl; Ranolazine dihydroch
Molecular FormulaC24H35Cl2N3O4
Molecular Weight500.46
Purity≥98 (HPLC)
Boiling Point624.1ºC at 760 mmHg
Melting Point222-229.5 °C (lit.)
Appearancepowder
Water SolubilityH2O: 10 mg/mL, soluble
Storage ConditionDesiccate at RT
ApplicationRanolazine dihydrochloride has antiarrhythmic activity.
HTC2942000000
PubChem ID24278795
MDL NumberMFCD03788770
SMILESCl.Cl.COc1ccccc1OCC(O)CN2CCN(CC2)CC(=O)Nc3c(C)cccc3C
InChI1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H
InChI KeyRJNSNFZXAZXOFX-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/12269_1_95635_56_6.pdf
Use ofRanolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). IC50 value:Target: sodium-dependent calcium channelRanolazine is currently approved for use in chronic angina. The basis for this use is likely related to inhibition of late sodium channels with resultant beneficial downstream effects. Randomized clinical trials have demonstrated an improvement in exercise capacity and reduction in angina episodes with ranolazine. Properties Name Ranolazine dihydrochloride Synonym More Synonyms Ranolazine dihydrochloride Biological Activity Description Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). IC50 value:Target: sodium-dependent calcium channelRanolazine is currently approved for use in chronic angina. The basis for this use is likely related to inhibition of late sodium channels with resultant beneficial downstream effects. Randomized clinical trials have demonstrated an improvement in exercise capacity and reduction in angina episodes with ranolazine. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease References [1]. Hawwa N, Menon V. Ranolazine: Clinical Applications and Therapeutic Basis. Am J Cardiovasc Drugs. 2013 Jan 19. [2]. Keating GM. Ranolazine: A Review of Its Use as Add-On Therapy in Patients with Chronic Stable Angina Pectoris. Drugs. 2013 Jan;73(1):55-73. [4]. Shryock JC, Belardinelli L. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br J Pharmacol. 2008 Mar;153(6):1128-32. Epub 2007 Dec 10. [5]. Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10. Chemical & Physical Properties Exact Mass 499.200470 PSA 74.27000 LogP 3.86080 Appearance of Characters solid | off-white InChIKey RJNSNFZXAZXOFX-UHFFFAOYSA-N Storage condition Desiccate at RT Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2942000000
Transport InfoProduct name: Ranolazine dihydrochloride
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