CAS Number57-47-6
SynonymsEserine Blue; Antilirium; (-)-Eserine; EINECS 200-332-8; Eserine; Physostigmine; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol Methylcarbamate (Ester); MFCD00151090; (3aS,8aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate; Physostigmine (USP); (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol methylcarbamate (ester); [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate
Molecular FormulaC22H27O5N3
Molecular Weight413.47
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point422.3±55.0 °C at 760 mmHg
Melting Point102-104 °C(lit.)
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57-47-6 |
| Catalog No. | 2A-9012001 |
| Chinese Name | 毒扁豆碱 |
| Synonyms | Eserine Blue; Antilirium; (-)-Eserine; EINECS 200-332-8; Eserine; Physostigmine; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol Methylcarbamate (Ester); MFCD00151090; (3aS,8aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate; Physostigmine (USP); (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol methylcarbamate (ester); [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate |
| Molecular Formula | C22H27O5N3 |
| Molecular Weight | 413.47 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 422.3±55.0 °C at 760 mmHg |
| Melting Point | 102-104 °C(lit.) |
| Storage Condition | This product should be sealed and stored in a cool |
| Packaging | II |
| Application | Physostigmine (Eserine) is a reversible inhibitor of acetylcholinesterase (AChE). Physostigmine crosses the blood-brain barrier and increases acetylcholine levels in the brain. Physostigmine reverses |
| MDL Number | MFCD00135659 |
| SMILES | CNC(=O)Oc1ccc2c(c1)C1(C)CCN(C)C1N2C |
| InChI | InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 |
| InChI Key | PIJVFDBKTWXHHD-HIFRSBDPSA-N |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/12001_1_57_47_6.pdf |
| Bioactivity | Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and elevate acetylcholine levels in the brain. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE In Vivo Physostigmine (Eserine) (0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2]. Animal Model: Heterozygous transgenic mice (Tg(+) mice)[2] Dosage: 0.03, 0.1, and 0.3 mg/kg Administration: S.c.; daily for 6 weeks Result: Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals. References [1]. Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42(3):188‐189. [2]. Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl). 2005;181(1):145‐152. [3]. Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings?. Curr Opin Pediatr. 2007;19(2):201‐205. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 422.3±55.0 °C at 760 mmHg Melting Point 102-104 °C(lit.) Molecular Formula C15H21N3O2 Molecular Weight 275.346 Flash Point 209.2±31.5 °C Exact Mass 275.163391 PSA 44.81000 LogP 1.89 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.616 InChIKey PIJVFDBKTWXHHD-HIFRSBDPSA-N SMILES CNC(=O)Oc1ccc2c(c1)C1(C)CCN(C)C1N2C |
| Use of | Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and elevate acetylcholine levels in the brain. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3]. Properties Articles106 Name physostigmine Synonym More Synonyms Physostigmine Biological Activity Description Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and elevate acetylcholine levels in the brain. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE References [1]. Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42(3):188‐189. [3]. Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings?. Curr Opin Pediatr. 2007;19(2):201‐205. Chemical & Physical Properties Molecular Formula C15H21N3O2 Exact Mass 275.163391 PSA 44.81000 Index of Refraction 1.616 InChIKey PIJVFDBKTWXHHD-HIFRSBDPSA-N |
| Transport Info | Product Name: Physostigmine |
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