CAS Number3486-67-7
SynonymsCalystigine; 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium; MFCD00221758; palmatine; Burasaine; 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium; 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium; palmatin; berbericinine; 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium; o,o-dimethyldemethyleneberberine; Hindarinine; 5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium; Common fibraurea stem
Molecular FormulaC21H22NO4+
Molecular Weight352.41
Purity98%
Melting Point205ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3486-67-7 |
| Catalog No. | 2A-9011856 |
| Chinese Name | 黄藤素 |
| Synonyms | Calystigine; 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium; MFCD00221758; palmatine; Burasaine; 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium; 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium; palmatin; berbericinine; 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium; o,o-dimethyldemethyleneberberine; Hindarinine; 5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium; Common fibraurea stem |
| Molecular Formula | C21H22NO4+ |
| Molecular Weight | 352.41 |
| Purity | 98 |
| Melting Point | 205ºC |
| Storage Condition | Room Temperature |
| Application | Palmatine is an orally active, irreversible IDO-1 inhibitor. Palmatine can reduce colon damage, prevent intestinal flora imbalance and regulate tryptophan catabolism, thereby improving DSS-induced col |
| HTC | 2933990090 |
| MDL Number | C21H22NO4 |
| SMILES | COc1cc2c(cc1OC)-c1cc3ccc(OC)c(OC)c3c[n+]1CC2 |
| InChI | InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1 |
| InChI Key | QUCQEUCGKKTEBI-UHFFFAOYSA-N |
| MSDS | msds/11856_1_3486_67_7.pdf |
| Use of | Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1]. Properties Name palmatine Synonym More Synonyms palmatine Biological Activity Description Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO) Research Areas >> Inflammation/Immunology In Vitro Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM[1]. References [1]. Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46. Chemical & Physical Properties Molecular Formula C21H22NO4+ Exact Mass 352.154327 PSA 40.80000 LogP -1.12 InChIKey QUCQEUCGKKTEBI-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Berbinium, 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C21-H22-N-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T D6 B666 KN&TT&J GO1 HO1 PO1 QO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,129,1968 Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route CAS#:131543-46-9 N-(2,3-dimethox... CAS#:47355-66-8 CAS#:3486-67-7 Literature: Bian, Xiaoli; He, Langchong; Yang, Guangde Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1380 - 1383 7,8-dihydro-8hy... CAS#:221527-72-6 CAS#:3486-67-7 Literature: Wafo, Pascal; Nyasse, Barthelemy; Fontaine, Catherine Phytochemistry, 1999 , vol. 50, # 2 p. 279 - 281 CAS#:109806-78-2 CAS#:3486-67-7 Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383 Precursor & DownStream Precursor 2 CAS#:120-20-7 3,4-Dimethoxyph... CAS#:86-51-1 2,3-Dimethoxybe... DownStream 1 CAS#:16176-68-4 Palmaturbine |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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